PMID- 19639188
OWN - NLM
STAT- MEDLINE
DCOM- 20090924
LR  - 20171116
IS  - 1021-335X (Print)
IS  - 1021-335X (Linking)
VI  - 22
IP  - 3
DP  - 2009 Sep
TI  - Peroxisome proliferator-activated receptor delta and gastric cancer (Review).
PG  - 451-7
AB  - Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear 
      hormone receptor superfamily which form heterodimers with retinoid X receptors 
      (RXRs) in nucleus and bind to the PPAR response elements (PPREs) of target genes, 
      leading to a wide spectrum of physiological functions. With an improved 
      understanding of its physiological role, PPARdelta and its agonist have been 
      gaining attention in cancer research in recent years. Despite the paucity of 
      research concerning the direct relationship between PPARdelta and gastric cancer, 
      there is substantial evidence that PPARdelta may play a role in the development 
      of gastric cancer. This review focuses on recent literature describing the role 
      of PPARdelta, especially in its association with nuclear factor-kappaB 
      (NF-kappaB), interleukin-1beta (IL-1beta), cyclooxygenase-2 (COX-2) and 
      Wnt-beta-catenin/TCF-4 pathways on gastric tumorigenesis and highlights critical 
      discrepancies that need to be resolved for a more comprehensive understanding of 
      how this receptor modulates gastric tumorigenesis. The potential role of 
      PPARdelta as a therapeutic target in the treatment of gastric cancer deserves 
      further research focus.
FAU - Wu, Chung W
AU  - Wu CW
AD  - Department of Medicine and Therapeutics, Prince of Wales Hospital, Institute of 
      Digestive Disease, The Chinese University of Hong Kong, Hong Kong, PR China.
FAU - Yu, Jun
AU  - Yu J
FAU - Sung, Joseph J Y
AU  - Sung JJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Greece
TA  - Oncol Rep
JT  - Oncology reports
JID - 9422756
RN  - 0 (Basic Helix-Loop-Helix Leucine Zipper Transcription Factors)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Interleukin-1beta)
RN  - 0 (NF-kappa B)
RN  - 0 (PPAR delta)
RN  - 0 (TCF4 protein, human)
RN  - 0 (Transcription Factor 4)
RN  - 0 (Transcription Factors)
RN  - 0 (Wnt Proteins)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
SB  - IM
MH  - Animals
MH  - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
MH  - Cyclooxygenase 2/physiology
MH  - DNA-Binding Proteins/physiology
MH  - Humans
MH  - Interleukin-1beta/physiology
MH  - NF-kappa B/physiology
MH  - PPAR delta/*physiology
MH  - Stomach Neoplasms/*etiology
MH  - Transcription Factor 4
MH  - Transcription Factors/physiology
MH  - Wnt Proteins/physiology
RF  - 71
EDAT- 2009/07/30 09:00
MHDA- 2009/09/25 06:00
CRDT- 2009/07/30 09:00
PHST- 2009/07/30 09:00 [entrez]
PHST- 2009/07/30 09:00 [pubmed]
PHST- 2009/09/25 06:00 [medline]
PST - ppublish
SO  - Oncol Rep. 2009 Sep;22(3):451-7.