PMID- 19641656
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20231103
IS  - 1205-6626 (Print)
IS  - 1205-6626 (Linking)
VI  - 8
IP  - 2
DP  - 2003 Summer
TI  - Relation between N-terminal pro-brain natriuretic peptide values and invasively 
      measured left ventricular hemodynamic indices.
PG  - 91-4
AB  - BACKGROUND: Pro-brain natriuretic peptide (proBNP) is synthesized in the left 
      ventricle. In response to transmural pressure, it is secreted into the 
      circulation and consequently cleaved to yield the active hormone BNP and its 
      N-terminal fragment (NT-proBNP). Determination of NT-proBNP is used as an aid in 
      the diagnosis of left ventricular dysfunction. METHODS: We analyzed 
      NT-proBNP-levels before left-heart catheterization in 115 patients. At the end of 
      the study, we compared the NT-proBNP values to the invasively measured 
      hemodynamic indices (left ventricular ejection fraction, maximum change in 
      pressure over time [dP/dt(max)] and left ventricular end-diastolic pressure) and 
      the clinically observed New York Heart Association (NYHA) classifications. 
      RESULTS: A significant (P=0.008) increase of the NT-proBNP values was observed in 
      cases of low ejection fraction (less than 41%). Furthermore, a significant 
      (P=0.03) increase of the NT-proBNP values was measured in cases of heavily 
      reduced dP/dt(max) (less than 1500 mmHg/s). The increase of NT-proBNP values in 
      cases of high end-diastolic pressures was distinct but not significant. In the 
      clinical observation (NYHA classification), a significant increase of NT-proBNP 
      levels corresponded to increasing severity of heart failure. However, a large 
      standard deviation was seen in all groups. CONCLUSION: Concerning low ejection 
      fractions, a high end-diastolic pressure and strong reduced dP/dt(max) in all 
      cases an increase of pro-BNP-values was seen. However, the partly reported strong 
      correlation of the BNP value to the left ventricular ejection fraction, 
      dP/dt(max) and left ventricular end-diastolic pressure results was not found in 
      the cases of middle and moderate heart failure, in contrast to the clinical 
      observation. Regarding the large standard deviation, it may be possible to 
      discriminate an unfavourable course of heart failure in an early stage.
FAU - Gremmler, Bernhard
AU  - Gremmler B
AD  - Department of Cardiology, Marienhospital Bottrop, Germany;
FAU - Kunert, Matthias
AU  - Kunert M
FAU - Schleiting, Heinrich
AU  - Schleiting H
FAU - Kisters, Klaus
AU  - Kisters K
FAU - Ulbricht, Ludger J
AU  - Ulbricht LJ
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Exp Clin Cardiol
JT  - Experimental and clinical cardiology
JID - 9715903
PMC - PMC2716205
OTO - NOTNLM
OT  - Heart failure
OT  - Left heart catheterization
OT  - Left ventricular hemodynamics
OT  - N-terminal pro-brain natriuretic peptide
EDAT- 2003/07/01 00:00
MHDA- 2003/07/01 00:01
PMCR- 2003/06/01
CRDT- 2009/07/31 09:00
PHST- 2009/07/31 09:00 [entrez]
PHST- 2003/07/01 00:00 [pubmed]
PHST- 2003/07/01 00:01 [medline]
PHST- 2003/06/01 00:00 [pmc-release]
AID - ecc08091 [pii]
PST - ppublish
SO  - Exp Clin Cardiol. 2003 Summer;8(2):91-4.