PMID- 19642887
OWN - NLM
STAT- MEDLINE
DCOM- 20100811
LR  - 20220318
IS  - 1530-8898 (Electronic)
IS  - 0898-929X (Linking)
VI  - 22
IP  - 8
DP  - 2010 Aug
TI  - The neural basis of personal goal processing when envisioning future events.
PG  - 1701-13
LID - 10.1162/jocn.2009.21314 [doi]
AB  - Episodic future thinking allows humans to mentally simulate virtually infinite 
      future possibilities, yet this device is fundamentally goal-directed and should 
      not be equated with fantasizing or wishful thinking. The purpose of this fMRI 
      study was to investigate the neural basis of such goal-directed processing during 
      future-event simulation. Participants were scanned while they imagined future 
      events that were related to their personal goals (personal future events) and 
      future events that were plausible but unrelated to their personal goals 
      (nonpersonal future events). Results showed that imaging personal future events 
      elicited stronger activation in ventral medial prefrontal cortex (MPFC) and 
      posterior cingulate cortex (PCC) compared to imaging nonpersonal future events. 
      Moreover, these brain activations overlapped with activations elicited by a 
      second task that assessed semantic self-knowledge (i.e., making judgments on 
      one's own personality traits), suggesting that ventral MPFC and PCC mediate 
      self-referential processing across different functional domains. It is suggested 
      that these brain regions may support a collection of processes that evaluate, 
      code, and contextualize the relevance of mental representations with regard to 
      personal goals. The implications of these findings for the understanding of the 
      function instantiated by the default network of the brain are also discussed.
FAU - D'Argembeau, Arnaud
AU  - D'Argembeau A
AD  - Departmentof Cognitive Sciences, University of Liege, Liege, Belgium. 
      a.dargembeau@ulg.ac.be
FAU - Stawarczyk, David
AU  - Stawarczyk D
FAU - Majerus, Steve
AU  - Majerus S
FAU - Collette, Fabienne
AU  - Collette F
FAU - Van der Linden, Martial
AU  - Van der Linden M
FAU - Feyers, Dorothee
AU  - Feyers D
FAU - Maquet, Pierre
AU  - Maquet P
FAU - Salmon, Eric
AU  - Salmon E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cogn Neurosci
JT  - Journal of cognitive neuroscience
JID - 8910747
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Brain Mapping
MH  - Cerebral Cortex/blood supply/*physiology
MH  - Female
MH  - Forecasting
MH  - *Goals
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Neuropsychological Tests
MH  - Oxygen/blood
MH  - Psychological Theory
MH  - *Self Concept
MH  - Semantics
MH  - Thinking/*physiology
MH  - Young Adult
EDAT- 2009/08/01 09:00
MHDA- 2010/08/12 06:00
CRDT- 2009/08/01 09:00
PHST- 2009/08/01 09:00 [entrez]
PHST- 2009/08/01 09:00 [pubmed]
PHST- 2010/08/12 06:00 [medline]
AID - 10.1162/jocn.2009.21314 [doi]
PST - ppublish
SO  - J Cogn Neurosci. 2010 Aug;22(8):1701-13. doi: 10.1162/jocn.2009.21314.