PMID- 19642908
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20151119
IS  - 1557-7465 (Electronic)
IS  - 1079-9907 (Linking)
VI  - 29
IP  - 11
DP  - 2009 Nov
TI  - Predictive markers of blood cytokine and chemokine in recurrent brain infarction.
PG  - 729-34
LID - 10.1089/jir.2009.0012 [doi]
AB  - The mechanism of the inflammatory response in the vascular wall in 
      atherothrombosis and during the progression of atherosclerosis has attracted 
      attention. We focused on the potential usefulness of inflammatory markers in 
      chronic recurrent brain infarction, and analyzed the role of inflammatory markers 
      in atherosclerosis of the intracranial artery. The subjects were 2 groups of 
      patients treated between 2004 and 2006: a group of outpatients with recurrent 
      infarction (group RI), who developed atherothrombotic brain infarction twice; 
      another group of outpatients with brain infarction without recurrence (group BI), 
      who developed brain infarction once and remained free of recurrence for >1 year; 
      and a group of control subjects with normal brain magnetic resonance imaging 
      (MRI) and magnetic resonance angiography (MRA) (group C). Plasma samples were 
      collected from each group of patients for the simultaneous measurement of 17 
      kinds of candidate inflammatory markers, using a fluorescent microbead array 
      system, and the results were compared with head MRA findings. The levels of 
      high-sensitivity C-reactive protein (hsCRP) and monocyte chemoattractant 
      protein-1 (MCP-1) were significantly higher in group RI patients than in groups C 
      and BI. Subjects with a hsCRP level > or =0.3 and a MCP-1 level > or =200 in the 
      serum have, respectively, a 1.92 and 2.98 relative risk to have a potential 
      recurrent infarction. Regarding the relation of inflammatory marker levels with 
      MRA findings, group RI showed significantly higher levels of hsCRP at M1 lesions 
      and MCP-1 at A1 and M1 lesions than group BI (P < 0.05). In conclusion, the MCP-1 
      level as well as hsCRP in the blood can be a potential predictive marker of 
      recurrent thrombotic brain infarction, and may reflect inflammation that promotes 
      intracranial large-artery atherosclerosis.
FAU - Kuriyama, Nagato
AU  - Kuriyama N
AD  - Department of Neurology, Kyoto Prefectural University of Medicine, 465 
      Kawaramachi-hirokoji, Kamigyo-ku, Kyoto, Japan. nkuriyam@koto.kpu-m.ac.jp
FAU - Mizuno, Toshiki
AU  - Mizuno T
FAU - Kita, Masakazu
AU  - Kita M
FAU - Nagakane, Yoshinari
AU  - Nagakane Y
FAU - Hosomi, Akiko
AU  - Hosomi A
FAU - Harada, Sanae
AU  - Harada S
FAU - Takeda, Kazuo
AU  - Takeda K
FAU - Ozasa, Kotaro
AU  - Ozasa K
FAU - Yamada, Kei
AU  - Yamada K
FAU - Tokuda, Takahiko
AU  - Tokuda T
FAU - Watanabe, Yoshiyuki
AU  - Watanabe Y
FAU - Nakagawa, Masanori
AU  - Nakagawa M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Interferon Cytokine Res
JT  - Journal of interferon & cytokine research : the official journal of the 
      International Society for Interferon and Cytokine Research
JID - 9507088
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Inflammation Mediators)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Biomarkers/*metabolism
MH  - Brain Infarction/blood/*diagnosis/pathology/physiopathology
MH  - C-Reactive Protein/*metabolism
MH  - Chemokine CCL2/*blood
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/*metabolism
MH  - Intracranial Arteriosclerosis
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Recurrence
EDAT- 2009/08/01 09:00
MHDA- 2010/11/17 06:00
CRDT- 2009/08/01 09:00
PHST- 2009/08/01 09:00 [entrez]
PHST- 2009/08/01 09:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 10.1089/jir.2009.0012 [doi]
PST - ppublish
SO  - J Interferon Cytokine Res. 2009 Nov;29(11):729-34. doi: 10.1089/jir.2009.0012.