PMID- 19644219
OWN - NLM
STAT- MEDLINE
DCOM- 20091207
LR  - 20190819
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 73
IP  - 10
DP  - 2009 Oct
TI  - High ratio of myeloid dendritic cells to plasmacytoid dendritic cells in blood of 
      patients with acute coronary syndrome.
PG  - 1914-9
AB  - BACKGROUND: Dendritic cells (DCs) stimulate T-cells to participate in the 
      inflammatory processes that promote the destruction of vulnerable plaques. The 
      relationship between circulating levels of myeloid DCs (mDCs) and plasmacytoid 
      DCs (pDCs) in patients with acute coronary syndrome (ACS) was evaluated. METHODS 
      AND RESULTS: Blood samples were obtained from 39 patients with ACS, 41 patients 
      with stable angina pectoris (SAP) and 43 controls. The proportion of mDCs tended 
      to be lower in the ACS group than in the SAP group and controls. Interleukin-12 
      levels associated with mDCs were significantly higher in the ACS group than in 
      control group. The proportion of pDCs was significantly lower in the ACS groups 
      than in the other two groups. Interferon-alpha levels secreted by pDCs, however, 
      were not significantly different among the 3 groups. The ratio of mDCs to pDCs 
      >or=4 is an important value for distinguishing ACS from SAP patients and control 
      patients through receiver operating characteristic analysis (sensitivity; 85.0%, 
      specificity; 83.4%). CONCLUSIONS: The ratio of mDCs to pDCs may be a useful 
      marker for detecting ACS and the existence of vulnerable plaques.
FAU - Fukunaga, Takashi
AU  - Fukunaga T
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, Kumamoto, Japan.
FAU - Soejima, Hirofumi
AU  - Soejima H
FAU - Irie, Atsushi
AU  - Irie A
FAU - Fukushima, Ryuichiro
AU  - Fukushima R
FAU - Oe, Yoko
AU  - Oe Y
FAU - Kawano, Hiroaki
AU  - Kawano H
FAU - Sumida, Hitoshi
AU  - Sumida H
FAU - Kaikita, Koichi
AU  - Kaikita K
FAU - Sugiyama, Seigo
AU  - Sugiyama S
FAU - Nishimura, Yasuharu
AU  - Nishimura Y
FAU - Ogawa, Hisao
AU  - Ogawa H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090731
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 0 (Biomarkers)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interferon-alpha)
RN  - 187348-17-0 (Interleukin-12)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
CIN - Circ J. 2009 Oct;73(10):1799-800. PMID: 19779274
MH  - Acute Coronary Syndrome/diagnosis/*immunology
MH  - Aged
MH  - Aged, 80 and over
MH  - Angina Pectoris/diagnosis/*immunology
MH  - Biomarkers/blood
MH  - C-Reactive Protein/metabolism
MH  - Case-Control Studies
MH  - Cell Count
MH  - Cell Separation
MH  - Coronary Artery Disease/diagnosis/*immunology
MH  - Dendritic Cells/*immunology
MH  - Diagnosis, Differential
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Inflammation Mediators/blood
MH  - Interferon-alpha/blood
MH  - Interleukin-12/blood
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Myeloid Cells/*immunology
MH  - Odds Ratio
MH  - Predictive Value of Tests
MH  - ROC Curve
MH  - Risk Assessment
MH  - Rupture
EDAT- 2009/08/01 09:00
MHDA- 2009/12/16 06:00
CRDT- 2009/08/01 09:00
PHST- 2009/08/01 09:00 [entrez]
PHST- 2009/08/01 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - JST.JSTAGE/circj/CJ-08-1193 [pii]
AID - 10.1253/circj.cj-08-1193 [doi]
PST - ppublish
SO  - Circ J. 2009 Oct;73(10):1914-9. doi: 10.1253/circj.cj-08-1193. Epub 2009 Jul 31.