PMID- 19644477
OWN - NLM
STAT- MEDLINE
DCOM- 20091201
LR  - 20090731
IS  - 1523-1755 (Electronic)
IS  - 0085-2538 (Linking)
VI  - 76
IP  - 4
DP  - 2009 Aug
TI  - Potential restoration of HDL function with apolipoprotein A-I mimetic peptide in 
      end-stage renal disease.
PG  - 359-61
LID - 10.1038/ki.2009.205 [doi]
AB  - High-density lipoprotein (HDL) cholesterol level is low in dialysis patients. The 
      HDL that is present is dysfunctional, failing to protect low-density lipoprotein 
      (LDL) from oxidation and reduce levels of oxidized LDL. Addition of the orally 
      absorbable amphipathic peptide 4-F to LDL obtained from dialysis patients 
      protects LDL from oxidation in vitro and reduces the capacity of oxidized LDL to 
      induce expression of monocyte chemoattractant protein-1 (MCP-1) by vascular 
      endothelial function in culture, potentially providing a tool to reduce 
      cardiovascular risk in dialysis patients.
FAU - Kaysen, George A
AU  - Kaysen GA
AD  - Division of Nephrology, Department of Medicine, University of California, Davis, 
      Davis, California 95616, USA. gakaysen@ucdavis.edu
LA  - eng
PT  - Comment
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Kidney Int
JT  - Kidney international
JID - 0323470
RN  - 0 (Apolipoprotein A-I)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Lipoproteins, HDL)
RN  - 0 (Peptides)
SB  - IM
CON - Kidney Int. 2009 Aug;76(4):437-44. PMID: 19471321
MH  - Apolipoprotein A-I/*chemistry
MH  - Cholesterol, HDL/*physiology
MH  - Humans
MH  - Kidney Failure, Chronic/*therapy
MH  - Lipoproteins, HDL/physiology
MH  - Molecular Mimicry
MH  - Peptides/*therapeutic use
RF  - 10
EDAT- 2009/08/01 09:00
MHDA- 2009/12/16 06:00
CRDT- 2009/08/01 09:00
PHST- 2009/08/01 09:00 [entrez]
PHST- 2009/08/01 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - S0085-2538(15)53990-2 [pii]
AID - 10.1038/ki.2009.205 [doi]
PST - ppublish
SO  - Kidney Int. 2009 Aug;76(4):359-61. doi: 10.1038/ki.2009.205.