PMID- 19644918
OWN - NLM
STAT- MEDLINE
DCOM- 20091013
LR  - 20181201
IS  - 1521-1878 (Electronic)
IS  - 0265-9247 (Linking)
VI  - 31
IP  - 9
DP  - 2009 Sep
TI  - Pannexins, distant relatives of the connexin family with specific cellular 
      functions?
PG  - 953-74
LID - 10.1002/bies.200800236 [doi]
AB  - Intercellular communication (IC) is mediated by gap junctions (GJs) and 
      hemichannels, which consist of proteins. This has been particularly well 
      documented for the connexin (Cx) family. Initially, Cxs were thought to be the 
      only proteins capable of GJ formation in vertebrates. About 10 years ago, 
      however, a new GJ-forming protein family related to invertebrate innexins (Inxs) 
      was discovered in vertebrates, and named the pannexin (Panx) family. Panxs, which 
      are structurally similar to Cxs, but evolutionarily distinct, have been shown to 
      be co-expressed with Cxs in vertebrates. Both protein families show distinct 
      properties and have their own particular function. Identification of the 
      mechanisms that control Panx channel gating is a major challenge for future work. 
      In this review, we focus on the specific properties and role of Panxs in normal 
      and pathological conditions.
FAU - D'hondt, Catheleyne
AU  - D'hondt C
AD  - Laboratory of Molecular and Cellular Signalling, KULeuven, Campus Gasthuisberg 
      O/N, Leuven, Belgium.
FAU - Ponsaerts, Raf
AU  - Ponsaerts R
FAU - De Smedt, Humbert
AU  - De Smedt H
FAU - Bultynck, Geert
AU  - Bultynck G
FAU - Himpens, Bernard
AU  - Himpens B
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Bioessays
JT  - BioEssays : news and reviews in molecular, cellular and developmental biology
JID - 8510851
RN  - 0 (Connexins)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
SB  - IM
MH  - Adenosine Triphosphate/metabolism
MH  - Animals
MH  - Cell Communication
MH  - Connexins/chemistry/*metabolism
MH  - Humans
MH  - Intercellular Junctions/chemistry/metabolism
MH  - Ion Channel Gating
MH  - Protein Transport
RF  - 314
EDAT- 2009/08/01 09:00
MHDA- 2009/10/14 06:00
CRDT- 2009/08/01 09:00
PHST- 2009/08/01 09:00 [entrez]
PHST- 2009/08/01 09:00 [pubmed]
PHST- 2009/10/14 06:00 [medline]
AID - 10.1002/bies.200800236 [doi]
PST - ppublish
SO  - Bioessays. 2009 Sep;31(9):953-74. doi: 10.1002/bies.200800236.