PMID- 19648126
OWN - NLM
STAT- MEDLINE
DCOM- 20100219
LR  - 20220330
IS  - 1468-2060 (Electronic)
IS  - 0003-4967 (Linking)
VI  - 69
IP  - 2
DP  - 2010 Feb
TI  - Prediction of radiographic progression in rheumatoid arthritis and the role of 
      antibodies against mutated citrullinated vimentin: results from a 10-year 
      prospective study.
PG  - 345-51
LID - 10.1136/ard.2009.113092 [doi]
AB  - OBJECTIVES: Anti-citrullinated peptide antibodies (ACPAs) are established as 
      useful predictors of radiographic progression in rheumatoid arthritis (RA). The 
      main objective of this study was to test the prognostic capacity of the recently 
      developed test for anti-mutated citrullinated vimentin (anti-MCV). METHODS: A 
      cohort of 238 patients with RA was followed longitudinally for 10 years; 125 
      patients with complete x ray sets were included in the main analyses. Radiographs 
      were scored according to the van der Heijde modified Sharp score (SHS). Patients 
      were analysed for anti-MCV and anti-cyclic citrullinated peptide (CCP), and were 
      genotyped for human leukocyte antigen (HLA)-DRB1 "shared epitope" (SE) and 
      protein tyrosine phosphatase, non-receptor type 22 (PTPN22) 1858T. RESULTS: 
      Anti-MCV and anti-CCP were strongly associated with regard to status and level. 
      Both antibodies were associated with SE, but only anti-MCV was significantly 
      associated with PTPN22 1858T. A positive anti-MCV test increased the odds of 
      radiographic progression by 7.3 (95% confidence interval (CI) 3.2 to 16.5) 
      compared to 5.7 (95% CI 2.6 to 12.5) for a positive anti-CCP. Presence of MCV 
      antibodies gave an average increase in the total SHS of 30 U compared to an 
      average increase of 25 U for the presence of CCP antibodies. Anti-MCVs were more 
      strongly associated to progression in erosions than joint space narrowing. 
      Associations remained after adjustment for other predictors of radiographic 
      progression. The odds of progression increased with increasing anti-MCV level. 
      CONCLUSIONS: Presence of anti-MCV predicted joint damage, and the strength of 
      this prediction was at least as strong as for anti-CCP. Antibody status showed a 
      stronger association to bone than to cartilage destruction. This study also 
      indicates that higher anti-MCV levels add prognostic information compared to 
      their mere presence or absence.
FAU - Syversen, S W
AU  - Syversen SW
AD  - Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway. 
      s.w.syversen@medisin.uio.no
FAU - Goll, G L
AU  - Goll GL
FAU - van der Heijde, D
AU  - van der Heijde D
FAU - Landewe, R
AU  - Landewe R
FAU - Lie, B A
AU  - Lie BA
FAU - Odegard, S
AU  - Odegard S
FAU - Uhlig, T
AU  - Uhlig T
FAU - Gaarder, P I
AU  - Gaarder PI
FAU - Kvien, T K
AU  - Kvien TK
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090730
PL  - England
TA  - Ann Rheum Dis
JT  - Annals of the rheumatic diseases
JID - 0372355
RN  - 0 (Autoantibodies)
RN  - 0 (Autoantigens)
RN  - 0 (Biomarkers)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Peptides, Cyclic)
RN  - 0 (Vimentin)
RN  - 0 (cyclic citrullinated peptide)
RN  - 29VT07BGDA (Citrulline)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arthritis, Rheumatoid/*diagnostic imaging/genetics/immunology
MH  - Autoantibodies/*blood
MH  - Autoantigens/immunology
MH  - Biomarkers/blood
MH  - Citrulline/*immunology
MH  - Disease Progression
MH  - Female
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Hand Joints/diagnostic imaging/pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Peptides, Cyclic/immunology
MH  - Prognosis
MH  - Prospective Studies
MH  - Radiography
MH  - Vimentin/*immunology
EDAT- 2009/08/04 09:00
MHDA- 2010/02/20 06:00
CRDT- 2009/08/04 09:00
PHST- 2009/08/04 09:00 [entrez]
PHST- 2009/08/04 09:00 [pubmed]
PHST- 2010/02/20 06:00 [medline]
AID - ard.2009.113092 [pii]
AID - 10.1136/ard.2009.113092 [doi]
PST - ppublish
SO  - Ann Rheum Dis. 2010 Feb;69(2):345-51. doi: 10.1136/ard.2009.113092. Epub 2009 Jul 
      30.