PMID- 19649323
OWN - NLM
STAT- MEDLINE
DCOM- 20091102
LR  - 20211020
IS  - 1553-7374 (Electronic)
IS  - 1553-7366 (Print)
IS  - 1553-7366 (Linking)
VI  - 5
IP  - 7
DP  - 2009 Jul
TI  - Influence of dendritic cells on viral pathogenicity.
PG  - e1000384
LID - 10.1371/journal.ppat.1000384 [doi]
LID - e1000384
AB  - Although most viral infections cause minor, if any, symptoms, a certain number 
      result in serious illness. Viral disease symptoms result both from direct viral 
      replication within host cells and from indirect immunopathological consequences. 
      Dendritic cells (DCs) are key determinants of viral disease outcome; they 
      activate immune responses during viral infection and direct T cells toward 
      distinct T helper type responses. Certain viruses are able to skew cytokine 
      secretion by DCs inducing and/or downregulating the immune system with the aim of 
      facilitating and prolonging release of progeny. Thus, the interaction of DCs with 
      viruses most often results in the absence of disease or complete recovery when 
      natural functions of DCs prevail, but may lead to chronic illness or death when 
      these functions are outmanoeuvred by viruses in the exploitation of DCs.
FAU - Freer, Giulia
AU  - Freer G
AD  - Retrovirus Center and Virology Section, Department of Experimental Pathology, 
      University of Pisa, Pisa, Italy. freer@biomed.unipi.it
FAU - Matteucci, Donatella
AU  - Matteucci D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20090731
PL  - United States
TA  - PLoS Pathog
JT  - PLoS pathogens
JID - 101238921
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology/virology
MH  - Host-Pathogen Interactions
MH  - Humans
MH  - Virus Diseases/*immunology/virology
MH  - Viruses/*pathogenicity
PMC - PMC2712770
COIS- The authors have declared that no competing interests exist.
EDAT- 2009/08/04 09:00
MHDA- 2009/11/03 06:00
PMCR- 2009/07/31
CRDT- 2009/08/04 09:00
PHST- 2009/08/04 09:00 [entrez]
PHST- 2009/08/04 09:00 [pubmed]
PHST- 2009/11/03 06:00 [medline]
PHST- 2009/07/31 00:00 [pmc-release]
AID - 08-PLPA-RV-1370R2 [pii]
AID - 10.1371/journal.ppat.1000384 [doi]
PST - ppublish
SO  - PLoS Pathog. 2009 Jul;5(7):e1000384. doi: 10.1371/journal.ppat.1000384. Epub 2009 
      Jul 31.