PMID- 19649981
OWN - NLM
STAT- MEDLINE
DCOM- 20091105
LR  - 20090803
IS  - 2040-3445 (Electronic)
IS  - 1464-8431 (Linking)
VI  - 11
IP  - 4
DP  - 2009 Aug
TI  - Cell therapy for liver disease.
PG  - 364-74
AB  - The clinical demand for whole organ transplantation for the treatment of 
      end-stage liver disease far outstrips supply. As a result, research efforts have 
      focused on hepatocyte therapies to support this scarce clinical resource, 
      including the investigation of alternative cell sources, in particular bone 
      marrow cells (BMCs). In animal models of metabolic liver disease, adopting 
      strategies that provide a selective advantage for transplanted hepatocytes have 
      proved to be highly effective in repopulating recipient livers, and the current 
      relatively poor success rate of hepatocyte transplants in humans can be 
      attributed to the lack of a clinically applicable procedure to induce a similar 
      repopulation of the human liver. Autologous BMCs have been transplanted in a 
      number of clinical trials involving patients with liver cirrhosis; modest 
      improvements in liver health have been reported, but the mechanisms responsible 
      for these effects are currently unknown. Transplanted hepatocytes can effectively 
      repopulate a metabolically deficient liver, provided that a selective advantage 
      exists for the donor cells. Some reports suggest that BMCs can differentiate into 
      hepatocytes, but for the treatment of cirrhosis, the primary goal is to render 
      the ingressing cells capable of degrading the excessive collagen associated with 
      the disease. This review presents the progress and discusses some of the problems 
      that need to be overcome in the field of cell transplantation for the treatment 
      of metabolic and fibrogenic liver diseases.
FAU - Alison, Malcolm R
AU  - Alison MR
AD  - Institute of Cell and Molecular Science, Centre for Diabetes and Metabolic 
      Medicine, London, UK. m.alison@qmul.ac.uk
FAU - Islam, Shahriar
AU  - Islam S
FAU - Lim, Susan M L
AU  - Lim SM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Curr Opin Mol Ther
JT  - Current opinion in molecular therapeutics
JID - 100891485
SB  - IM
MH  - Animals
MH  - *Cell Transplantation
MH  - Disease Models, Animal
MH  - Humans
MH  - Liver Diseases/*therapy
MH  - Liver Regeneration
RF  - 72
EDAT- 2009/08/04 09:00
MHDA- 2009/11/06 06:00
CRDT- 2009/08/04 09:00
PHST- 2009/08/04 09:00 [entrez]
PHST- 2009/08/04 09:00 [pubmed]
PHST- 2009/11/06 06:00 [medline]
PST - ppublish
SO  - Curr Opin Mol Ther. 2009 Aug;11(4):364-74.