PMID- 19650162
OWN - NLM
STAT- MEDLINE
DCOM- 20110121
LR  - 20131121
IS  - 1099-1166 (Electronic)
IS  - 0885-6230 (Linking)
VI  - 25
IP  - 4
DP  - 2010 Apr
TI  - Antipsychotics and risk of cerebrovascular events in treatment of behavioural and 
      psychological symptoms of dementia in Hong Kong: a hospital-based, retrospective, 
      cohort study.
PG  - 362-70
LID - 10.1002/gps.2347 [doi]
AB  - OBJECTIVE: The purpose of this study was to investigate the risk of 
      cerebrovascular adverse events (CVAEs) in patients with behavioural and 
      psychological symptoms of dementia (BPSD) treated with typical or atypical 
      antipsychotics in Hong Kong METHOD: This was a retrospective cohort study. 
      Patients aged 65 or above, diagnosed with Alzheimer's disease, vascular or mixed 
      dementia, and first attended the psychiatric service of our unit between 1st 
      January 2000 to 30th June 2007 were studied. The patients were divided into three 
      groups according to their antipsychotic usage. They were compared on 
      sociodemographic and clinical characteristics. The risk of CVAEs was studied by 
      means of Cox regression analysis. RESULTS: The studied cohort consisted of 1089 
      patients. The antipsychotic non-user, typical and atypical users groups consisted 
      of 363, 654 and 72 patients, respectively. Incidence rate of CVAE for the three 
      groups were 44.6/1000, 32.7/1000 and 49.6/1000 person years, respectively. The 
      risk of developing CVAEs did not differ in typical or atypical antipsychotic user 
      groups compared with non-user group. The adjusted hazard ratio of typical and 
      atypical antipsychotic user groups were 0.964 (95% CI = 0.584-1.591) and 1.036 
      (95% CI = 0.350-3.066), respectively. Subgroup analyses of individual 
      antipsychotic did not show a significant increase in risk of CVAEs. CONCLUSION: 
      This study showed that there was no statistical difference in risk of 
      cerebrovascular events in treatment of BPSD with typical and atypical 
      antipsychotics compared with non-user group. Nonetheless, given the side effects 
      of antipsychotics, prescription of antipsychotics should be reserved for severe 
      and distressing symptoms with careful consideration.
FAU - Chan, Man-chak
AU  - Chan MC
AD  - Department of Psychiatry, Pamela Youde Nethersole Eastern Hospital, Hong Kong. 
      cmc418@ha.org.hk
FAU - Chong, Catherine Shiu-yin
AU  - Chong CS
FAU - Wu, Anna Ying-king
AU  - Wu AY
FAU - Wong, Kai-choi
AU  - Wong KC
FAU - Dunn, Eva Lai-wah
AU  - Dunn EL
FAU - Tang, Orlando Wai-nang
AU  - Tang OW
FAU - Chan, Wah-fat
AU  - Chan WF
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Geriatr Psychiatry
JT  - International journal of geriatric psychiatry
JID - 8710629
RN  - 0 (Antipsychotic Agents)
RN  - L6UH7ZF8HC (Risperidone)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Antipsychotic Agents/*adverse effects
MH  - Cerebrovascular Disorders/*chemically induced/epidemiology
MH  - Dementia/*drug therapy/psychology
MH  - Female
MH  - Hong Kong/epidemiology
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Risperidone/*adverse effects
EDAT- 2009/08/04 09:00
MHDA- 2011/01/22 06:00
CRDT- 2009/08/04 09:00
PHST- 2009/08/04 09:00 [entrez]
PHST- 2009/08/04 09:00 [pubmed]
PHST- 2011/01/22 06:00 [medline]
AID - 10.1002/gps.2347 [doi]
PST - ppublish
SO  - Int J Geriatr Psychiatry. 2010 Apr;25(4):362-70. doi: 10.1002/gps.2347.