PMID- 19650788
OWN - NLM
STAT- MEDLINE
DCOM- 20100728
LR  - 20100507
IS  - 1365-2265 (Electronic)
IS  - 0300-0664 (Linking)
VI  - 72
IP  - 4
DP  - 2010 Apr
TI  - Bone mineral density analysis in patients with primary hyperparathyroidism 
      associated with multiple endocrine neoplasia type 1 after total 
      parathyroidectomy.
PG  - 462-8
LID - 10.1111/j.1365-2265.2009.03672.x [doi]
AB  - OBJECTIVE: Limited data have been reported on the effect of parathyroidectomy 
      (PTx) on bone mineral density (BMD) in the setting of patients with 
      hyperparathyroidism (HPT) associated with multiple endocrine neoplasia type 1 
      (MEN1). This study investigates the impact of total PTx on BMD in patients with 
      HPT/MEN1. DESIGN AND PATIENTS: A case series study was performed in a tertiary 
      academic hospital. A total of 16 HPT/MEN1 patients from six families harbouring 
      MEN1 germline mutations were subjected to total PTx followed by parathyroid 
      auto-implant in the forearm. MEASUREMENTS: Bone mineral density values were 
      assessed using dual-energy X-ray absorptiometry. RESULTS: Before PTx, reduced BMD 
      (Z-score <-2.0) was highly prevalent in the proximal one-third of the distal 
      radius (1/3 DR) (50%), lumbar spine (LS) (43.7%), ultradistal radius (UDR) 
      (43.7%), femoral neck (FN) (25%) and total femur (TF) (18.7%) in the patients. 
      Fifteen months after PTx, we observed a BMD improvement in the LS (from 0.843 to 
      0.909 g/cm(2); +8.4%, P = 0.001), FN (from 0.745 to 0.798 g/cm(2); +7.7%, P = 
      0.0001) and TF (from 0.818 to 0.874 g/cm(2); +6.9%, P < 0.0001). No significant 
      change was noticed in the 1/3 DR and UDR after PTx. CONCLUSIONS: This data 
      confirmed BMD recovery in the LS and FN after PTx in HPT/MEN1 patients. We also 
      documented a significant BMD increase in the TF and no change in both the 1/3 DR 
      and UDR BMD after PTx. Our data suggest that LS and proximal femur are the most 
      informative sites to evaluate the short-term BMD outcome after PTx in HPT/MEN1 
      subjects.
FAU - Coutinho, Flavia L
AU  - Coutinho FL
AD  - Endocrine Genetics Unit (LIM-25), Division of Endocrinology, Hospital das 
      Clinicas, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.
FAU - Lourenco, Delmar M Jr
AU  - Lourenco DM Jr
FAU - Toledo, Rodrigo A
AU  - Toledo RA
FAU - Montenegro, Fabio L M
AU  - Montenegro FL
FAU - Correia-Deur, Joya E M
AU  - Correia-Deur JE
FAU - Toledo, Sergio P A
AU  - Toledo SP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090724
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
SB  - IM
MH  - Absorptiometry, Photon
MH  - Adult
MH  - *Bone Density
MH  - Female
MH  - Humans
MH  - Hyperparathyroidism, Primary/*surgery
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*surgery
MH  - *Parathyroidectomy
EDAT- 2009/08/05 09:00
MHDA- 2010/07/29 06:00
CRDT- 2009/08/05 09:00
PHST- 2009/08/05 09:00 [entrez]
PHST- 2009/08/05 09:00 [pubmed]
PHST- 2010/07/29 06:00 [medline]
AID - CEN3672 [pii]
AID - 10.1111/j.1365-2265.2009.03672.x [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 2010 Apr;72(4):462-8. doi: 
      10.1111/j.1365-2265.2009.03672.x. Epub 2009 Jul 24.