PMID- 19651194
OWN - NLM
STAT- MEDLINE
DCOM- 20091130
LR  - 20131121
IS  - 1879-3169 (Electronic)
IS  - 0378-4274 (Linking)
VI  - 191
IP  - 1
DP  - 2009 Dec 1
TI  - Long-term intake of a high zinc diet causes iron deficiency anemia accompanied by 
      reticulocytosis and extra-medullary erythropoiesis.
PG  - 15-9
LID - 10.1016/j.toxlet.2009.07.024 [doi]
AB  - To elucidate the pathophysiology of zinc (Zn)-induced iron (Fe) deficiency anemia 
      (IDA), we examined hemoglobin (Hb) concentrations, hematocrit (Ht) levels, 
      numbers of circulating red blood cells (RBC) and reticulocytes, values of mean 
      corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular 
      hemoglobin concentration (MCHC), serum Zn, Fe and erythropoietin (EPO) 
      concentrations and histopathological changes in the bone marrow, spleen and liver 
      using rats fed with a standard or high Zn diet for 20 weeks. Rats fed with the 
      high Zn diet exhibited a significant decrease in Hb concentrations, Ht levels and 
      MCV, MCH and MCHC values, indicating microcytic hypochromic anemia characterized 
      by Fe deficiency. Also, a marked decrease in serum Fe concentrations was seen in 
      rats fed with the high Zn diet relative to rats fed with the standard diet. 
      Interestingly, the number of RBC was comparable in both groups of rats, although 
      a decrease in the number of RBC is ordinarily seen in IDA. There were 
      reticulocytosis and extra-medullary erythropoiesis in the spleen and an increase 
      in serum EPO concentrations in rats fed with the high Zn diet vs. those on the 
      standard diet. These observations suggest that both reticulocytosis and 
      extra-medullary erythropoiesis in the spleen played a role in maintaining the 
      number of RBC in rats fed with the high Zn diet, preventing further progression 
      of anemia. Further, increased production of EPO may be involved in the induction 
      of reticulocytosis and extra-medullary erythropoiesis in the spleen.
FAU - Yanagisawa, Hiroyuki
AU  - Yanagisawa H
AD  - Department of Public Health and Environmental Medicine, Faculty of Medicine, The 
      Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato-ku, Tokyo 
      105-8461, Japan. hryanagisawa@jikei.ac.jp
FAU - Miyakoshi, Yuichi
AU  - Miyakoshi Y
FAU - Kobayashi, Koh
AU  - Kobayashi K
FAU - Sakae, Kensaku
AU  - Sakae K
FAU - Kawasaki, Ichiro
AU  - Kawasaki I
FAU - Suzuki, Yuji
AU  - Suzuki Y
FAU - Tamura, Jun'ichi
AU  - Tamura J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090803
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - E1UOL152H7 (Iron)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Anemia, Hypochromic/blood/*chemically induced
MH  - Animals
MH  - Blood Cell Count
MH  - Body Weight/drug effects
MH  - Bone Marrow/drug effects/pathology
MH  - *Diet
MH  - Erythrocyte Count
MH  - Erythrocyte Indices
MH  - Erythropoiesis/*drug effects
MH  - Hematocrit
MH  - Iron/blood
MH  - Liver/drug effects/pathology
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reticulocyte Count
MH  - Reticulocytosis/*drug effects
MH  - Spleen/drug effects/pathology
MH  - Zinc/blood/*toxicity
EDAT- 2009/08/05 09:00
MHDA- 2009/12/16 06:00
CRDT- 2009/08/05 09:00
PHST- 2009/04/02 00:00 [received]
PHST- 2009/07/24 00:00 [revised]
PHST- 2009/07/25 00:00 [accepted]
PHST- 2009/08/05 09:00 [entrez]
PHST- 2009/08/05 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - S0378-4274(09)01366-6 [pii]
AID - 10.1016/j.toxlet.2009.07.024 [doi]
PST - ppublish
SO  - Toxicol Lett. 2009 Dec 1;191(1):15-9. doi: 10.1016/j.toxlet.2009.07.024. Epub 
      2009 Aug 3.