PMID- 19651895
OWN - NLM
STAT- MEDLINE
DCOM- 20091103
LR  - 20220408
IS  - 1098-5549 (Electronic)
IS  - 0270-7306 (Print)
IS  - 0270-7306 (Linking)
VI  - 29
IP  - 20
DP  - 2009 Oct
TI  - Nuclear-cytoplasmic shuttling of menin regulates nuclear translocation of 
      beta-catenin.
PG  - 5477-87
LID - 10.1128/MCB.00335-09 [doi]
AB  - Menin, which is encoded by the multiple endocrine neoplasia type 1 (MEN1) gene, 
      is a tumor suppressor and transcriptional regulator. Menin controls proliferation 
      and apoptosis of cells, especially pancreatic beta cells. We have found that 
      menin contains two functional nuclear export signals and that there is nuclear 
      accumulation of beta-catenin in Men1-null mouse embryonic fibroblasts and 
      insulinoma tissues from beta-cell-specific Men1 knockout mice. It is reported 
      that the deregulation of Wnt/beta-catenin signaling caused by inactivation of 
      tumor suppressors results in abnormal development or tumorigenesis. We further 
      revealed that overexpression of menin reduces beta-catenin nuclear accumulation 
      and its transcriptional activity. Menin is able to directly interact with 
      beta-catenin and carry beta-catenin out of the nucleus via nuclear-cytoplasmic 
      shuttling in a CRM1-dependent manner. These results imply that menin may control 
      cell proliferation through suppression of Wnt/beta-catenin signaling.
FAU - Cao, Yanan
AU  - Cao Y
AD  - Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, 
      Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 
      200025, China.
FAU - Liu, Ruixin
AU  - Liu R
FAU - Jiang, Xiuli
AU  - Jiang X
FAU - Lu, Jieli
AU  - Lu J
FAU - Jiang, Jingjing
AU  - Jiang J
FAU - Zhang, Changxian
AU  - Zhang C
FAU - Li, Xiaoying
AU  - Li X
FAU - Ning, Guang
AU  - Ning G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090803
PL  - United States
TA  - Mol Cell Biol
JT  - Molecular and cellular biology
JID - 8109087
RN  - 0 (Men1 protein, mouse)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Wnt Proteins)
RN  - 0 (beta Catenin)
SB  - IM
MH  - Active Transport, Cell Nucleus
MH  - Animals
MH  - Cell Nucleus/*metabolism
MH  - Cytoplasm/*metabolism
MH  - HeLa Cells
MH  - Humans
MH  - Mice
MH  - Mice, Knockout
MH  - Proto-Oncogene Proteins/genetics/*metabolism
MH  - Signal Transduction/genetics/physiology
MH  - Wnt Proteins/*metabolism
MH  - beta Catenin/*metabolism
PMC - PMC2756891
EDAT- 2009/08/05 09:00
MHDA- 2009/11/05 06:00
PMCR- 2010/04/01
CRDT- 2009/08/05 09:00
PHST- 2009/08/05 09:00 [entrez]
PHST- 2009/08/05 09:00 [pubmed]
PHST- 2009/11/05 06:00 [medline]
PHST- 2010/04/01 00:00 [pmc-release]
AID - MCB.00335-09 [pii]
AID - 0335-09 [pii]
AID - 10.1128/MCB.00335-09 [doi]
PST - ppublish
SO  - Mol Cell Biol. 2009 Oct;29(20):5477-87. doi: 10.1128/MCB.00335-09. Epub 2009 Aug 
      3.