PMID- 1965317
OWN - NLM
STAT- MEDLINE
DCOM- 19910603
LR  - 20191028
IS  - 1120-009X (Print)
IS  - 1120-009X (Linking)
VI  - 2
IP  - 5
DP  - 1990 Oct
TI  - Comparative in-vitro activity of piperacillin and piperacillin plus tazobactam 
      towards beta-lactamase producing clinical isolates.
PG  - 295-9
AB  - The authors evaluated the in-vitro antibacterial activity of piperacillin alone 
      and of piperacillin combined with tazobactam, a new beta-lactamase inhibitor, on 
      398 clinical isolates, both Gram-positive and Gram-negative. The 
      piperacillin/tazobactam combination was evaluated in the fixed ratio 8:1. The 
      vast majority of the microorganisms tested had reduced susceptibility to 
      piperacillin (minimum inhibitory concentration (MIC) range 0.12- greater than 256 
      mg/l) due to beta-lactamase production. The following results were obtained: 
      against Haemophilus influenzae, tazobactam was effective in reducing the MICs of 
      piperacillin by 512 fold. The activity of piperacillin/tazobactam was lower 
      against Pseudomonas sp., while some activity was demonstrated against some 
      strains of Klebsiella. Good activity was seen not only against 
      methicillin-susceptible (MS) staphylococci but also against some 
      methicillin-resistant (MR) strains. In the latter, the combination of 
      piperacillin/tazobactam was active only if the strains showed beta-lactamase 
      production. These findings are interesting above all in regard to the synergistic 
      effect demonstrated against MR beta-lactamase producing staphylococci and the 
      Klebsiella-Enterobacter-Serratia (KES) group.
FAU - Stefani, S
AU  - Stefani S
AD  - Institute of Microbiology, University of Catania, Italy.
FAU - Castiglia, P
AU  - Castiglia P
FAU - Maida, A
AU  - Maida A
FAU - Muresu, E
AU  - Muresu E
FAU - Mezzatesta, M L
AU  - Mezzatesta ML
FAU - Nicoletti, G
AU  - Nicoletti G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - J Chemother
JT  - Journal of chemotherapy (Florence, Italy)
JID - 8907348
RN  - 0 (beta-Lactamase Inhibitors)
RN  - 87-53-6 (Penicillanic Acid)
RN  - EC 3.5.2.6 (beta-Lactamases)
RN  - SE10G96M8W (Tazobactam)
RN  - X00B0D5O0E (Piperacillin)
SB  - IM
MH  - Drug Synergism
MH  - Drug Therapy, Combination/pharmacology
MH  - Gram-Negative Bacteria/*drug effects/enzymology
MH  - Gram-Positive Bacteria/*drug effects/enzymology
MH  - Microbial Sensitivity Tests
MH  - Penicillanic Acid/*pharmacology
MH  - Piperacillin/*pharmacology
MH  - Tazobactam
MH  - beta-Lactamase Inhibitors
MH  - beta-Lactamases/*biosynthesis
EDAT- 1990/10/01 00:00
MHDA- 1990/10/01 00:01
CRDT- 1990/10/01 00:00
PHST- 1990/10/01 00:00 [pubmed]
PHST- 1990/10/01 00:01 [medline]
PHST- 1990/10/01 00:00 [entrez]
AID - 10.1080/1120009x.1990.11739032 [doi]
PST - ppublish
SO  - J Chemother. 1990 Oct;2(5):295-9. doi: 10.1080/1120009x.1990.11739032.