PMID- 19654304
OWN - NLM
STAT- MEDLINE
DCOM- 20090915
LR  - 20090814
IS  - 1538-7445 (Electronic)
IS  - 0008-5472 (Linking)
VI  - 69
IP  - 16
DP  - 2009 Aug 15
TI  - Tissue selectivity in multiple endocrine neoplasia type 1-associated 
      tumorigenesis.
PG  - 6371-4
LID - 10.1158/0008-5472.CAN-09-0678 [doi]
AB  - The phenotype of the multiple endocrine neoplasia type 1 (MEN1) syndrome cannot 
      be explained solely by the expression pattern of the predisposing gene MEN1 and 
      its encoded protein, menin. This review addresses putative factors determining 
      MEN1-associated tissue-selective tumorigenesis. Menin's interaction with 
      mixed-lineage leukemia protein-containing histone methyl transferase (MLL-HMT) 
      complex mediates tissue-selective tumor-suppressing and tumor-promoting effects 
      of menin, and as such could be decisive for the predisposition of individual 
      tissues to MEN1-associated tumorigenesis. In tissues in which menin acts as a 
      tumor suppressor, tumorigenesis could depend on the inability of such tissues to 
      adequately compensate for MEN1 gene loss, whereas the variable clinical 
      presentation of MEN1 in individual patients could be a reflection of additional 
      epigenetic factors and/or modifier genes. Further research on this topic may 
      facilitate development of novel therapeutic strategies that could prevent or 
      delay the onset of MEN1-associated tumorigenesis.
FAU - Gracanin, Ana
AU  - Gracanin A
AD  - Department of Clinical Sciences of Companion Animals, Faculty of Veterinary 
      Medicine, Utrecht University, Utrecht, The Netherlands.
FAU - Dreijerink, Koen M A
AU  - Dreijerink KM
FAU - van der Luijt, Rob B
AU  - van der Luijt RB
FAU - Lips, Cornelis J M
AU  - Lips CJ
FAU - Hoppener, Jo W M
AU  - Hoppener JW
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090804
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Animals
MH  - Cell Transformation, Neoplastic/*genetics
MH  - Gene Deletion
MH  - Humans
MH  - Models, Biological
MH  - Multiple Endocrine Neoplasia Type 1/complications/genetics
MH  - Neoplasms/etiology/*genetics
MH  - Organ Specificity/genetics
MH  - Proto-Oncogene Proteins/*genetics/physiology
RF  - 26
EDAT- 2009/08/06 09:00
MHDA- 2009/09/16 06:00
CRDT- 2009/08/06 09:00
PHST- 2009/08/06 09:00 [entrez]
PHST- 2009/08/06 09:00 [pubmed]
PHST- 2009/09/16 06:00 [medline]
AID - 0008-5472.CAN-09-0678 [pii]
AID - 10.1158/0008-5472.CAN-09-0678 [doi]
PST - ppublish
SO  - Cancer Res. 2009 Aug 15;69(16):6371-4. doi: 10.1158/0008-5472.CAN-09-0678. Epub 
      2009 Aug 4.