PMID- 19654407
OWN - NLM
STAT- MEDLINE
DCOM- 20091202
LR  - 20211020
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 114
IP  - 14
DP  - 2009 Oct 1
TI  - Donor-recipient mismatches in MHC class I chain-related gene A in unrelated donor 
      transplantation lead to increased incidence of acute graft-versus-host disease.
PG  - 2884-7
LID - 10.1182/blood-2009-05-223172 [doi]
AB  - The polymorphic products of major histocompatibility complex class I-related 
      chain A (MICA) genes are important in solid organ transplantation rejection. MICA 
      expression is limited to gut epithelium and may play a role in triggering acute 
      graft-versus-host disease (aGVHD). A total of 236 recipients of unrelated donor 
      transplantation were studied. Donor-recipient human leukocyte antigen (HLA) match 
      was 10/10 human leukocyte antigen (HLA-A, -B, -C, -DRB1, -DQB1) in 73% and MICA 
      mismatch in 8.4%. Because of physical vicinity of the loci, MICA mismatch was 
      significantly associated with mismatch at HLA-B and HLA-C. A higher rate of grade 
      II-IV aGVHD was seen in MICA-mismatched patients (80% vs 40%, P = .003) 
      irrespective of degree of HLA matching (HLA 10/10 match: 75% vs 39%, P = .02) and 
      HLA any mismatch (83% vs 46%, P = .003). The rate of grade II-IV gastrointestinal 
      aGVHD was also higher in MICA-mismatched patients (35% vs 17%, P = .05). We 
      conclude that MICA may represent novel a transplantation antigen recognized by 
      human allogeneic T cells. This study was registered at ClinicalTrials.gov 
      (Identifier NCT00506922).
FAU - Parmar, Simrit
AU  - Parmar S
AD  - Department of Stem Cell Transplantation and Cellular Therapy, University of Texas 
      MD Anderson Cancer Center, Houston, TX 77030, USA.
FAU - Del Lima, Marcos
AU  - Del Lima M
FAU - Zou, Yizhou
AU  - Zou Y
FAU - Patah, Poliana A
AU  - Patah PA
FAU - Liu, Ping
AU  - Liu P
FAU - Cano, Pedro
AU  - Cano P
FAU - Rondon, Gabriela
AU  - Rondon G
FAU - Pesoa, Susana
AU  - Pesoa S
FAU - de Padua Silva, Leandro
AU  - de Padua Silva L
FAU - Qazilbash, Muzaffar H
AU  - Qazilbash MH
FAU - Hosing, Chitra
AU  - Hosing C
FAU - Popat, Uday
AU  - Popat U
FAU - Kebriaei, Partow
AU  - Kebriaei P
FAU - Shpall, Elizabeth J
AU  - Shpall EJ
FAU - Giralt, Sergio
AU  - Giralt S
FAU - Champlin, Richard E
AU  - Champlin RE
FAU - Stastny, Peter
AU  - Stastny P
FAU - Fernandez-Vina, Marcelo
AU  - Fernandez-Vina M
LA  - eng
SI  - ClinicalTrials.gov/NCT00506922
PT  - Journal Article
DEP - 20090804
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
SB  - IM
CIN - Blood. 2009 Nov 19;114(21):4753-4; author reply 4754-5. PMID: 19965715
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Blood Donors
MH  - Female
MH  - Genes, MHC Class I/*genetics
MH  - Genotype
MH  - Graft Rejection
MH  - Graft vs Host Disease/*etiology/*mortality
MH  - *Hematopoietic Stem Cell Transplantation
MH  - *Histocompatibility
MH  - Histocompatibility Testing
MH  - Humans
MH  - Incidence
MH  - Leukemia, Myeloid, Acute/*therapy
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - Risk Factors
MH  - Survival Rate
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC4784289
EDAT- 2009/08/06 09:00
MHDA- 2009/12/16 06:00
PMCR- 2009/10/01
CRDT- 2009/08/06 09:00
PHST- 2009/08/06 09:00 [entrez]
PHST- 2009/08/06 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PHST- 2009/10/01 00:00 [pmc-release]
AID - S0006-4971(20)36825-7 [pii]
AID - 2009/223172 [pii]
AID - 10.1182/blood-2009-05-223172 [doi]
PST - ppublish
SO  - Blood. 2009 Oct 1;114(14):2884-7. doi: 10.1182/blood-2009-05-223172. Epub 2009 
      Aug 4.