PMID- 19654916
OWN - NLM
STAT- MEDLINE
DCOM- 20091008
LR  - 20220318
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 117
IP  - 7
DP  - 2009 Jul
TI  - Organochlorine exposure and incidence of diabetes in a cohort of Great Lakes 
      sport fish consumers.
PG  - 1076-82
LID - 10.1289/ehp.0800281 [doi]
AB  - BACKGROUND: Studies have demonstrated ubiquitous human exposure to persistent 
      organic pollutants (POPs) such as p,p'-diphenyldichloroethene (DDE) and 
      polychlorinated biphenyls (PCBs). Although there is considerable evidence that 
      POP exposures are associated with prevalent diabetes, these studies do not 
      establish causality because the cross-sectional study design does not allow for 
      assessment of temporality of the exposure-disease association. Prospective 
      studies, however, have been lacking. OBJECTIVES: This study was designed to 
      determine whether POP body burdens are related to incidence of diabetes in a 
      cohort of Great Lakes sport fish consumers. METHODS: The cohort was established 
      in the early 1990s and followed through 2005. We tested serum for DDE and PCB 
      congeners and assessed diabetes diagnosis, demographics, and fish consumption. 
      Associations of diabetes with exposures were examined prospectively in 
      participants without diabetes in 1994-1995, followed through 2005. Annual percent 
      changes in DDE and PCB-132/153 from 1994 to 2005 were examined by diabetes 
      status. RESULTS: DDE exposure was associated with incident diabetes. Incident 
      diabetes was not associated with mono-ortho PCB-118, total PCBs, or years of 
      sport fish consumption. Annual percent change in DDE and PCB-132/153 did not 
      differ significantly by diabetes status. CONCLUSIONS: This study demonstrates an 
      association between DDE exposure and incident diabetes. The findings of an 
      association of DDE with incident diabetes and the lack of effect of diabetes on 
      annual percent change in POPs do not support the hypothesis that associations of 
      POPs with diabetes are attributable to reverse causality. Additional studies 
      should address the biological pathways by which DDE could affect glucose 
      homeostasis.
FAU - Turyk, Mary
AU  - Turyk M
AD  - Division of Epidemiology and Biostatistics, School of Public Health, University 
      of Illinois-Chicago, Chicago, Illinois 60612, USA. mturyk1@uic.edu
FAU - Anderson, Henry
AU  - Anderson H
FAU - Knobeloch, Lynda
AU  - Knobeloch L
FAU - Imm, Pamela
AU  - Imm P
FAU - Persky, Victoria
AU  - Persky V
LA  - eng
GR  - H75/ATH59832/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20090306
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Water Pollutants, Chemical)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Diabetes Mellitus/blood/*epidemiology
MH  - Dichlorodiphenyl Dichloroethylene/blood/toxicity
MH  - *Environmental Exposure
MH  - Female
MH  - Fishes
MH  - Fresh Water/analysis
MH  - Humans
MH  - Hydrocarbons, Chlorinated/blood/*toxicity
MH  - Male
MH  - Middle Aged
MH  - Polychlorinated Biphenyls/blood/toxicity
MH  - Water Pollutants, Chemical/blood/*toxicity
PMC - PMC2717133
OTO - NOTNLM
OT  - DDE
OT  - Great Lakes sport fish
OT  - PCB
OT  - diabetes
OT  - dioxin
OT  - prospective
OT  - sport fish
EDAT- 2009/08/06 09:00
MHDA- 2009/10/09 06:00
PMCR- 2009/07/01
CRDT- 2009/08/06 09:00
PHST- 2008/10/13 00:00 [received]
PHST- 2009/03/06 00:00 [accepted]
PHST- 2009/08/06 09:00 [entrez]
PHST- 2009/08/06 09:00 [pubmed]
PHST- 2009/10/09 06:00 [medline]
PHST- 2009/07/01 00:00 [pmc-release]
AID - ehp-117-1076 [pii]
AID - 10.1289/ehp.0800281 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2009 Jul;117(7):1076-82. doi: 10.1289/ehp.0800281. Epub 
      2009 Mar 6.