PMID- 1965544 OWN - NLM STAT- MEDLINE DCOM- 19910624 LR - 20171206 IS - 0393-6155 (Print) IS - 0393-6155 (Linking) VI - 5 IP - 4 DP - 1990 Oct-Dec TI - Serum NSE, CEA, CT, CA 15-3 levels in human lung cancer. PG - 198-202 AB - The significance of neuron specific enolase (NSE) was investigated in comparison with other tumor markers (CEA, CT, CA 15-3) used in the diagnosis and treatment monitoring of lung cancer. As previously described, the calcitonin assay proved to have very low sensitivity for small cell lung cancer (SCLC). The serum NSE assay was, however, shown to be a useful diagnostic aid for discrimination between histologically different lung cancers, and therefore this assay may be a valuable tool for treatment monitoring in SCLC patients. CA 15-3, also an unspecific marker, showed similar sensitivity to the NSE assay in SCLC patients, the sensitivity being higher than CEA in non small cell lung cancer (NSCLC). FAU - Nutini, S AU - Nutini S AD - Pneumology Unit, USL 10/D, Firenze, Italy. FAU - Cappelli, G AU - Cappelli G FAU - Benucci, A AU - Benucci A FAU - Catalani, C AU - Catalani C FAU - Nozzoli, F AU - Nozzoli F LA - eng PT - Journal Article PL - United States TA - Int J Biol Markers JT - The International journal of biological markers JID - 8712411 RN - 0 (Antigens, Tumor-Associated, Carbohydrate) RN - 0 (Biomarkers, Tumor) RN - 0 (Carcinoembryonic Antigen) RN - 9007-12-9 (Calcitonin) RN - EC 4.2.1.11 (Phosphopyruvate Hydratase) SB - IM MH - Adult MH - Aged MH - Antigens, Tumor-Associated, Carbohydrate/blood MH - Biomarkers, Tumor/*blood MH - Calcitonin/blood MH - Carcinoembryonic Antigen/blood MH - Carcinoma, Non-Small-Cell Lung/blood/enzymology/immunology MH - Carcinoma, Small Cell/blood/enzymology/immunology MH - Female MH - Humans MH - Lung Neoplasms/*blood/enzymology/immunology MH - Male MH - Middle Aged MH - Phosphopyruvate Hydratase/blood EDAT- 1990/10/01 00:00 MHDA- 1990/10/01 00:01 CRDT- 1990/10/01 00:00 PHST- 1990/10/01 00:00 [pubmed] PHST- 1990/10/01 00:01 [medline] PHST- 1990/10/01 00:00 [entrez] PST - ppublish SO - Int J Biol Markers. 1990 Oct-Dec;5(4):198-202.