PMID- 19655728
OWN - NLM
STAT- MEDLINE
DCOM- 20091230
LR  - 20220316
IS  - 1936-086X (Electronic)
IS  - 1936-0851 (Print)
IS  - 1936-0851 (Linking)
VI  - 3
IP  - 9
DP  - 2009 Sep 22
TI  - Increased heating efficiency and selective thermal ablation of malignant tissue 
      with DNA-encased multiwalled carbon nanotubes.
PG  - 2667-73
LID - 10.1021/nn900368b [doi]
AB  - Nanoparticles, including multiwalled carbon nanotubes (MWNTs), strongly absorb 
      near-infrared (nIR) radiation and efficiently convert absorbed energy to released 
      heat which can be used for localized hyperthermia applications. We demonstrate 
      for the first time that DNA-encasement increases heat emission following nIR 
      irradiation of MWNTs, and DNA-encased MWNTs can be used to safely eradicate a 
      tumor mass in vivo. Upon irradiation of DNA-encased MWNTs, heat is generated with 
      a linear dependence on irradiation time and laser power. DNA-encasement resulted 
      in a 3-fold reduction in the concentration of MWNTs required to impart a 10 
      degrees C temperature increase in bulk solution temperature. A single treatment 
      consisting of intratumoral injection of MWNTs (100 microL of a 500 microg/mL 
      solution) followed by laser irradiation at 1064 nm, 2.5 W/cm(2) completely 
      eradicated PC3 xenograft tumors in 8/8 (100%) of nude mice. Tumors that received 
      only MWNT injection or laser irradiation showed growth rates indistinguishable 
      from nontreated control tumors. Nonmalignant tissues displayed no long-term 
      damage from treatment. The results demonstrate that DNA-encased MWNTs are more 
      efficient at converting nIR irradiation into heat compared to nonencased MWNTs 
      and that DNA-encased MWNTs can be used safely and effectively for the selective 
      thermal ablation of malignant tissue in vivo.
FAU - Ghosh, Supratim
AU  - Ghosh S
AD  - Department of Cancer Biology, Wake Forest University School of Medicine, 
      Winston-Salem, NC 27157, USA.
FAU - Dutta, Samrat
AU  - Dutta S
FAU - Gomes, Evan
AU  - Gomes E
FAU - Carroll, David
AU  - Carroll D
FAU - D'Agostino, Ralph Jr
AU  - D'Agostino R Jr
FAU - Olson, John
AU  - Olson J
FAU - Guthold, Martin
AU  - Guthold M
FAU - Gmeiner, William H
AU  - Gmeiner WH
LA  - eng
GR  - P30 CA012197/CA/NCI NIH HHS/United States
GR  - U01 CA102532/CA/NCI NIH HHS/United States
GR  - T32CA05964/CA/NCI NIH HHS/United States
GR  - CA102532/CA/NCI NIH HHS/United States
GR  - 2P30CA12197-25/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - ACS Nano
JT  - ACS nano
JID - 101313589
RN  - 0 (Nanotubes, Carbon)
RN  - 059QF0KO0R (Water)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Cell Line, Tumor
MH  - Cell Transformation, Neoplastic
MH  - DNA/*chemistry
MH  - Feasibility Studies
MH  - *Hot Temperature
MH  - *Laser Therapy
MH  - Male
MH  - Mice
MH  - Nanotubes, Carbon/*chemistry
MH  - Neoplasms/*pathology/*surgery
MH  - Solubility
MH  - Water/chemistry
PMC - PMC2748720
EDAT- 2009/08/07 09:00
MHDA- 2009/12/31 06:00
PMCR- 2009/09/22
CRDT- 2009/08/07 09:00
PHST- 2009/08/07 09:00 [entrez]
PHST- 2009/08/07 09:00 [pubmed]
PHST- 2009/12/31 06:00 [medline]
PHST- 2009/09/22 00:00 [pmc-release]
AID - 10.1021/nn900368b [doi]
PST - ppublish
SO  - ACS Nano. 2009 Sep 22;3(9):2667-73. doi: 10.1021/nn900368b.