PMID- 19657722
OWN - NLM
STAT- MEDLINE
DCOM- 20100310
LR  - 20221207
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 37
IP  - 1
DP  - 2010 Jan
TI  - No significant association between Fc receptor-like 3 gene polymorphisms and 
      human leukocyte antigen-B27 positive ankylosing spondylitis in Han Chinese 
      population.
PG  - 297-300
LID - 10.1007/s11033-009-9690-4 [doi]
AB  - Ankylosing spondylitis (AS) is a rheumatoid arthritis, which is a common 
      autoimmune disease with a complex genetic etiology. Although HLA-B27 has been 
      identified to be associated with AS, a number of other genes may also be involved 
      in the disease. Fc receptor-like 3 (FCRL3) gene has been shown to be associated 
      with rheumatoid arthritis in Japanese population. Here we aim to explore the 
      association FCRL3 gene and susceptibility to human leukocyte antigen 
      (HLA)-B27-positive AS in Han Chinese population. Among 169 AS patients, the 
      frequencies of C and T (rs7522061) in FCRL3 gene were 38.7 and 61.3%, 
      respectively; in 184 controls (HLA-B27-positive), the frequencies of C and T were 
      38.6 and 61.4%, respectively. The frequencies of alleles and genotype are not of 
      statistically significant difference in two groups (chi(2) = 0.000, P = 0.983; 
      chi(2) = 0.099, P = 0.952, respectively), but the distribution of HLA-B27 
      subtypes are statistically significant difference between cases and controls 
      (chi(2) = 8.214, P = 0.042). Our data reveal that the FCRL3 gene does not appear 
      associated with susceptibility to HLA-B27-positive AS in Han Chinese population.
FAU - Xia, Guo
AU  - Xia G
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, Anhui, China.
FAU - Pan, Faming
AU  - Pan F
FAU - Liao, Fangfang
AU  - Liao F
FAU - Tang, Xiaowu
AU  - Tang X
FAU - Ge, Rui
AU  - Ge R
FAU - Mei, Yang
AU  - Mei Y
FAU - Pan, Heping
AU  - Pan H
FAU - Xu, Shengqian
AU  - Xu S
FAU - Xu, Jianhua
AU  - Xu J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090806
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (FCRL3 protein, human)
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (Receptors, Immunologic)
SB  - IM
MH  - Adult
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - China
MH  - Ethnicity/*genetics
MH  - Female
MH  - Gene Frequency/genetics
MH  - *Genetic Predisposition to Disease
MH  - HLA-B27 Antigen/*genetics
MH  - Humans
MH  - Male
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Receptors, Immunologic/*genetics
MH  - Spondylitis, Ankylosing/*genetics/*immunology
EDAT- 2009/08/07 09:00
MHDA- 2010/03/11 06:00
CRDT- 2009/08/07 09:00
PHST- 2009/02/09 00:00 [received]
PHST- 2009/07/28 00:00 [accepted]
PHST- 2009/08/07 09:00 [entrez]
PHST- 2009/08/07 09:00 [pubmed]
PHST- 2010/03/11 06:00 [medline]
AID - 10.1007/s11033-009-9690-4 [doi]
PST - ppublish
SO  - Mol Biol Rep. 2010 Jan;37(1):297-300. doi: 10.1007/s11033-009-9690-4. Epub 2009 
      Aug 6.