PMID- 19658004
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20151119
IS  - 1369-1635 (Electronic)
IS  - 0953-7104 (Linking)
VI  - 20
IP  - 6
DP  - 2009 Sep
TI  - Correlation and association between plasma platelet-, monocyte- and endothelial 
      cell-derived microparticles in hypertensive patients with type 2 diabetes 
      mellitus.
PG  - 406-14
LID - 10.1080/09537100903114545 [doi]
AB  - Elevated platelet-derived mircoparticles (MP) (PDMP), endothelial cell-derived MP 
      (EDMP), and monocyte-derived MP (MDMP) concentrations are documented in almost 
      all thrombotic diseases. However, the intricate interactions between PDMP, MDMP 
      and EDMP in hypertensive patients with or without type 2 diabetes remains poorly 
      understood. Therefore, to clarify the correlation and association of MPs, we 
      measured and analysed the levels of MPs in 359 hypertensive patients. We compared 
      the results of chemokines, cell adhesion molecules, platelet activation markers 
      and microparticles in hypertensive patients with and without type 2 diabetes 
      mellitus. The levels of all markers were significantly higher in the hypertensive 
      patients with diabetes than in the non-diabetic patients. For hypertensive 
      patients with diabetes, univariate analysis showed that age, body mass index, 
      systolic blood pressure, high density lipoprotein cholesterol (HDL-CHO), 
      creatinine (CRTN), soluble P-selectin (sP-selectin), soluble E-selectin 
      (sE-selectin), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble CD40 
      ligand (sCD40L), regulated on activation normally T-cell expressed and secreted 
      (RANTES), monocyte chemotactic peptide-1 (MCP-1), MDMP and EDMP were 
      significantly associated with PDMP. In addition, systolic blood pressure, HDL 
      cholesterol, sP-selectin, sE-selectin, sVCAM-1, sCD40L, RANTES, MDMP and EDMP 
      were significant factors in the multivariate model with PDMP. Furthermore, a 
      correlation between plasma PDMP and MDMP or EDMP in hypertensive patients were 
      observed both with and without diabetes. These results suggest that the existence 
      of diabetes mellitus affects PDMP generation in hypertensive patients and that 
      enhanced plasma levels of PDMP and an association between the plasma levels of 
      PDMP, MDMP and EDMP may result in the development of atherothrombotic 
      complications in hypertensive patients.
FAU - Nomura, Shosaku
AU  - Nomura S
AD  - Division of Hematology, Kishiwada City Hospital, Kishiwada, Osaka, Japan. 
      shosaku-n@mbp.ocn.ne.jp
FAU - Inami, Norihito
AU  - Inami N
FAU - Shouzu, Akira
AU  - Shouzu A
FAU - Urase, Fumiaki
AU  - Urase F
FAU - Maeda, Yasuhiro
AU  - Maeda Y
LA  - eng
PT  - Journal Article
PL  - England
TA  - Platelets
JT  - Platelets
JID - 9208117
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Chemokines)
SB  - IM
MH  - Biomarkers/blood/metabolism
MH  - Blood Glucose/metabolism
MH  - Blood Pressure
MH  - Cell-Derived Microparticles/*metabolism/pathology
MH  - Chemokines/metabolism
MH  - Diabetes Mellitus, Type 2/*blood/complications/pathology
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Hypertension/*blood/complications/pathology
MH  - Male
MH  - Middle Aged
EDAT- 2009/08/07 09:00
MHDA- 2010/06/18 06:00
CRDT- 2009/08/07 09:00
PHST- 2009/08/07 09:00 [entrez]
PHST- 2009/08/07 09:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
AID - 913560930 [pii]
AID - 10.1080/09537100903114545 [doi]
PST - ppublish
SO  - Platelets. 2009 Sep;20(6):406-14. doi: 10.1080/09537100903114545.