PMID- 19659985
OWN - NLM
STAT- MEDLINE
DCOM- 20091102
LR  - 20131121
IS  - 1440-0960 (Electronic)
IS  - 0004-8380 (Linking)
VI  - 50
IP  - 3
DP  - 2009 Aug
TI  - Toxic epidermal necrolysis and neutropaenia: complications of omeprazole.
PG  - 207-10
LID - 10.1111/j.1440-0960.2009.00540.x [doi]
AB  - Worldwide, proton pump inhibitors (PPI) are one of the most frequently prescribed 
      drugs; however, up to 70% of patients taking these drugs have no appropriate 
      indication. Although PPI are relatively well tolerated, they are not free from 
      side-effects and several life-threatening complications are associated with them. 
      In the present report, a 43-year-old woman presented to her general practitioner 
      with an erythematous rash over her face and chest, having been started on 
      omeprazole for chronic abdominal bloating. Over the next 24 h she became 
      increasingly unwell and was admitted to hospital with shortness of breath, 
      pyrexia and the rash spreading over her back, arms and legs. Vesicles had now 
      started to appear within the erythematous regions over her upper body and within 
      24 h the rash became confluent and desquamative, spreading to involve her entire 
      body. A diagnosis of toxic epidermal necrolysis (TEN) was made. Despite 
      supportive treatment within a critical care setting, she became neutropaenic and 
      her skin loss became more extensive, resulting in 95% epidermal detachment. This 
      case highlights that TEN is a life-threatening condition associated with a high 
      incidence of morbidity and mortality. Optimal management requires early diagnosis 
      and transfer to a specialized unit. Clinicians need to be aware that PPI are not 
      free from side-effects and that their routine prescription should be strongly 
      discouraged.
FAU - Thakor, Avnesh S
AU  - Thakor AS
AD  - Intensive Care Unit, West Suffolk Hospital, Bury St Edmunds, UK. 
      asthakor@hotmail.com
FAU - Burke, Ailbhe
AU  - Burke A
FAU - Handfield-Jones, Susan
AU  - Handfield-Jones S
FAU - Sinha, Ayush
AU  - Sinha A
FAU - Palmer, Mike
AU  - Palmer M
FAU - Burns, Alys
AU  - Burns A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - Australia
TA  - Australas J Dermatol
JT  - The Australasian journal of dermatology
JID - 0135232
RN  - 0 (Insulin)
RN  - 0 (Proton Pump Inhibitors)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - Acute Kidney Injury/diagnosis/therapy
MH  - Adult
MH  - Biopsy, Needle
MH  - Combined Modality Therapy
MH  - Diabetes Mellitus, Type 1/diagnosis/drug therapy
MH  - Disease Progression
MH  - Dyspepsia/diagnosis/*drug therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunohistochemistry
MH  - Insulin/therapeutic use
MH  - Omeprazole/*adverse effects/therapeutic use
MH  - Proton Pump Inhibitors/*adverse effects/therapeutic use
MH  - Renal Dialysis
MH  - Risk Assessment
MH  - Stevens-Johnson Syndrome/*etiology/pathology/*therapy
RF  - 21
EDAT- 2009/08/08 09:00
MHDA- 2009/11/03 06:00
CRDT- 2009/08/08 09:00
PHST- 2009/08/08 09:00 [entrez]
PHST- 2009/08/08 09:00 [pubmed]
PHST- 2009/11/03 06:00 [medline]
AID - AJD540 [pii]
AID - 10.1111/j.1440-0960.2009.00540.x [doi]
PST - ppublish
SO  - Australas J Dermatol. 2009 Aug;50(3):207-10. doi: 
      10.1111/j.1440-0960.2009.00540.x.