PMID- 19661618
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20220318
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 18
IP  - 4
DP  - 2009
TI  - BDNF genetic variations increase the risk of Alzheimer's disease-related 
      depression.
PG  - 867-75
LID - 10.3233/JAD-2009-1191 [doi]
AB  - The gene encoding the brain-derived neurotrophic factor (BDNF) has been 
      demonstrated as a candidate for Alzheimer's disease-related depression (AD-D) 
      susceptibility. Additionally, an association between AD-D and the functional 
      valine to methionine (Val66Met) polymorphism has been reported. The aim of this 
      study was to assess the genetic contribution of other BDNF variants to AD-D. 
      Two-hundred forty-five AD patients were divided into two subgroups according to 
      the presence (AD-D) or the absence (AD-nD) of depressive symptoms. Four 
      single-nucleotide polymorphisms within BDNF gene were considered, i.e., C270T, 
      rs2049045 C/G, G196A (Val66Met), and G11757C. In our sample, 35.5% of patients (n 
      = 87) reported AD-related depressive symptoms. The individual SNP analysis showed 
      an association between G196A and G11757C genotypes and AD-D. Accordingly, 
      considering the allele frequencies, BDNF 196*A allele was significantly 
      overrepresented in AD-D compared to AD-nD (OR = 1.80, 95% CI = 1.19-2.72), as 
      well as BDNF 11757*C allele (OR = 1.90, 95% CI = 1.25-2.90). Haplotype analyses 
      revealed that the alleles at four loci (C270T, rs2049045 C/G, G196A, G11757C) 
      interacted to further increase the risk of AD-D. Compared to the most common 
      not-at-risk C-C-G-G haplotype, C-G-A-C (OR = 3.55, 95% CI = 1.44-8.76, P = 0.006) 
      and C-C-A-C haplotypes (OR = 1.72, 95% CI = 1.03-2.87, P = 0.037) were 
      overrepresented in AD-D. This study suggests that BDNF genetic variations play a 
      role in the susceptibility to AD-related depression.
FAU - Borroni, Barbara
AU  - Borroni B
AD  - Center for Aging Brain and Dementia, Department of Neurology, University of 
      Brescia, 1 -25100 Brescia, Italy. bborroni@inwind.it
FAU - Grassi, Mario
AU  - Grassi M
FAU - Archetti, Silvana
AU  - Archetti S
FAU - Costanzi, Chiara
AU  - Costanzi C
FAU - Bianchi, Marta
AU  - Bianchi M
FAU - Caimi, Luigi
AU  - Caimi L
FAU - Caltagirone, Carlo
AU  - Caltagirone C
FAU - Di Luca, Monica
AU  - Di Luca M
FAU - Padovani, Alessandro
AU  - Padovani A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Alzheimer Disease/epidemiology/*genetics/*psychology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Depression/complications/epidemiology/*genetics
MH  - Female
MH  - Gene Amplification
MH  - Genetic Predisposition to Disease/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Neuropsychological Tests
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
EDAT- 2009/08/08 09:00
MHDA- 2010/09/18 06:00
CRDT- 2009/08/08 09:00
PHST- 2009/08/08 09:00 [entrez]
PHST- 2009/08/08 09:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
AID - A8645G101064RU40 [pii]
AID - 10.3233/JAD-2009-1191 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2009;18(4):867-75. doi: 10.3233/JAD-2009-1191.