PMID- 19662597
OWN - NLM
STAT- MEDLINE
DCOM- 20090915
LR  - 20090807
IS  - 1121-8428 (Print)
IS  - 1121-8428 (Linking)
VI  - 22
IP  - 4
DP  - 2009 Jul-Aug
TI  - The "antibodyome": or, how to find antibodies?
PG  - 439-41
AB  - The importance of alloantibodies in acute and chronic allograft rejection has 
      been highlighted over the past few decades. Besides human leukocyte antigen (HLA) 
      antibodies, representing the most important group of antibodies in renal 
      transplantation, non-HLA antigens such as MHC class I polypeptide-related 
      sequence A (MICA) antibodies have also been implicated in renal allograft 
      outcome. However, the identification of alloantibodies and autoantibodies and 
      their antigens is technically difficult. Recently, Li and colleagues have 
      performed an integrative genomic analysis of serological responses to non-HLA 
      antigens in 18 pediatric renal transplant patients to identify new types of 
      antibodies and their tissue specificity by cross-mapping kidney 
      compartment-specific gene probes to protein targets on a protein array (1). 
      Several non-HLA targets were detected against kidney compartment-specific 
      antigens with the highest signal recognition for the renal pelvis. On the one 
      hand, this integrative approach may provide a powerful and cost-efficient tool to 
      detect autoantibodies involved in autoimmune diseases to investigate their 
      specificity, relevance and pathogenetic role. On the other hand, the clinical 
      relevance of these autoantibodies remains to be shown, and it should be explained 
      how mainly intracellular proteins can provide relevant antigens.
FAU - Mohebbi, Nilufar
AU  - Mohebbi N
AD  - Institute of Physiology and Zurich Center for Integrative Human Physiology 
      (ZIHP), Division of Nephroogy, University Hospital Zurich, Zurich, Switzerland. 
      nmohebbi@access.uzh.ch
FAU - Wagner, Carsten A
AU  - Wagner CA
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - J Nephrol
JT  - Journal of nephrology
JID - 9012268
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Autoantibodies/*analysis/immunology/physiology
MH  - Autoimmune Diseases/etiology
MH  - Humans
MH  - Kidney Transplantation/*immunology
EDAT- 2009/08/08 09:00
MHDA- 2009/09/16 06:00
CRDT- 2009/08/08 09:00
PHST- 2009/08/08 09:00 [entrez]
PHST- 2009/08/08 09:00 [pubmed]
PHST- 2009/09/16 06:00 [medline]
PST - ppublish
SO  - J Nephrol. 2009 Jul-Aug;22(4):439-41.