PMID- 19662619
OWN - NLM
STAT- MEDLINE
DCOM- 20100106
LR  - 20111117
IS  - 1520-7560 (Electronic)
IS  - 1520-7552 (Linking)
VI  - 25 Suppl 1
DP  - 2009 Sep
TI  - Physical inactivity and obesity: links with insulin resistance and type 2 
      diabetes mellitus.
PG  - S18-23
LID - 10.1002/dmrr.983 [doi]
AB  - Data from the health survey for England 2006, showed that the prevalence of type 
      2 diabetes mellitus (T2DM) has more than doubled in men and women since 1991. In 
      the USA certain States have a prevalence of T2DM of greater than 10%. Globally it 
      has been reported that this increase is by no means slowing down and that the 
      number of individuals with the disease is expected to rise from 171 million cases 
      reported in 2000 to 366 million by the year 2030. Physical inactivity and obesity 
      are two major risk factors for the development of T2DM. In this review we will 
      discuss evidence of an association between physical inactivity, obesity and T2DM 
      from prospective cohort studies and clinical trials. We will also discuss some of 
      the potential mechanisms that are thought to link obesity and physical inactivity 
      with the major pathophysiological precursor of T2DM, insulin resistance.
FAU - Venables, Michelle C
AU  - Venables MC
AD  - Exercise Metabolism Research Group, Human Performance Laboratory, School of Sport 
      and Exercise Sciences, The University of Birmingham, Edgbaston, Birmingham B15 
      2TT, UK. michelle.venables@brookes.ac.uk
FAU - Jeukendrup, Asker E
AU  - Jeukendrup AE
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Diabetes Metab Res Rev
JT  - Diabetes/metabolism research and reviews
JID - 100883450
RN  - 0 (Dietary Fats)
RN  - 0 (Fatty Acids)
RN  - 0 (Insulin)
SB  - IM
MH  - Adipose Tissue/metabolism
MH  - Clinical Trials as Topic
MH  - Diabetes Mellitus/epidemiology/etiology/physiopathology/prevention & control
MH  - Diabetes Mellitus, Type 2/*epidemiology/etiology/physiopathology/prevention & 
      control
MH  - Dietary Fats
MH  - Energy Intake
MH  - Exercise
MH  - Fatty Acids/metabolism
MH  - Female
MH  - Humans
MH  - Insulin/physiology
MH  - Male
MH  - Muscle, Skeletal/metabolism
MH  - Myocardium/metabolism
MH  - Obesity/*complications
MH  - Reproducibility of Results
MH  - Risk
MH  - Risk Assessment
RF  - 64
EDAT- 2009/08/08 09:00
MHDA- 2010/01/07 06:00
CRDT- 2009/08/08 09:00
PHST- 2009/08/08 09:00 [entrez]
PHST- 2009/08/08 09:00 [pubmed]
PHST- 2010/01/07 06:00 [medline]
AID - 10.1002/dmrr.983 [doi]
PST - ppublish
SO  - Diabetes Metab Res Rev. 2009 Sep;25 Suppl 1:S18-23. doi: 10.1002/dmrr.983.