PMID- 19664670
OWN - NLM
STAT- MEDLINE
DCOM- 20100129
LR  - 20211216
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 70
IP  - 12
DP  - 2009 Dec
TI  - Isoforms of human leukocyte antigen-G and their inhibitory receptors in human 
      kidney allograft acceptance.
PG  - 988-94
LID - 10.1016/j.humimm.2009.07.023 [doi]
AB  - Novel therapeutic strategies such as the modulation of dendritic cell and T-cell 
      function have exhibited great potential in clinical transplantation. Human 
      leukocyte antigen (HLA)-G is a molecule that plays a significant role in 
      establishing complex mechanisms to protect semiallogeneic fetuses from rejection 
      by the maternal immune system. The unique characteristics of both cell-surface 
      and soluble isoforms of HLA-G, the formation of disulfide-bonded dimers with the 
      potential to augment inhibitory receptor signaling, and the function of HLA-G as 
      a preferential ligand for the immunoglobulin-like transcript receptors make HLA-G 
      very important in fundamental approaches for the modulation of immune responses 
      to improve allogeneic graft survival in clinical transplantation. Experimental 
      data from several groups as well as our data from experiments involving 
      HLA-G-mediated human tolerogenic dendritic cells in vitro and receptor transgenic 
      mice in vivo indicate that different isoforms of HLA-G have various 
      immunomodulatory effects through the inhibitory receptors. This knowledge is 
      crucial in understanding mechanisms of prolongation of allograft survival. The 
      analyses of HLA-G isoforms and inhibitory receptors in patients with kidney 
      allograft and the relationship among different isoforms of HLA-G, inhibitory 
      receptors, their mediated immunoregulation, and graft acceptance or failure will 
      be discussed here.
FAU - Wu, Juan
AU  - Wu J
AD  - Center for Molecular Chaperone/Radiobiology and Cancer Virology, Department of 
      Medicine, Medical College of Georgia, Augusta, GA 30912, USA.
FAU - Zhang, Wei
AU  - Zhang W
FAU - Hernandez-Lopez, Pedro
AU  - Hernandez-Lopez P
FAU - Fabelo, Edward
AU  - Fabelo E
FAU - Parikh, Mehul
AU  - Parikh M
FAU - Mulloy, Laura L
AU  - Mulloy LL
FAU - Horuzsko, Anatolij
AU  - Horuzsko A
LA  - eng
GR  - R01 AI055923/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090805
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Antigens, CD)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (LILRB1 protein, human)
RN  - 0 (LILRB2 protein, human)
RN  - 0 (Leukocyte Immunoglobulin-like Receptor B1)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Protein Isoforms)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, KIR2DL5)
SB  - IM
MH  - Animals
MH  - Antigens, CD/immunology/metabolism
MH  - Dendritic Cells/*immunology
MH  - Graft Rejection/*immunology
MH  - Graft Survival/*immunology
MH  - HLA Antigens/genetics/*immunology
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/genetics/*immunology
MH  - Humans
MH  - Kidney Transplantation/*immunology
MH  - Leukocyte Immunoglobulin-like Receptor B1
MH  - Membrane Glycoproteins/immunology/metabolism
MH  - Mice
MH  - Mice, Transgenic
MH  - Protein Isoforms/immunology
MH  - Receptors, Immunologic/immunology/metabolism
MH  - Receptors, KIR2DL5
MH  - Signal Transduction/immunology
MH  - T-Lymphocyte Subsets/immunology
EDAT- 2009/08/12 09:00
MHDA- 2010/01/30 06:00
CRDT- 2009/08/12 09:00
PHST- 2009/06/25 00:00 [received]
PHST- 2009/07/29 00:00 [revised]
PHST- 2009/07/30 00:00 [accepted]
PHST- 2009/08/12 09:00 [entrez]
PHST- 2009/08/12 09:00 [pubmed]
PHST- 2010/01/30 06:00 [medline]
AID - S0198-8859(09)00198-0 [pii]
AID - 10.1016/j.humimm.2009.07.023 [doi]
PST - ppublish
SO  - Hum Immunol. 2009 Dec;70(12):988-94. doi: 10.1016/j.humimm.2009.07.023. Epub 2009 
      Aug 5.