PMID- 19664886
OWN - NLM
STAT- MEDLINE
DCOM- 20100503
LR  - 20100201
IS  - 1618-0631 (Electronic)
IS  - 0344-0338 (Linking)
VI  - 206
IP  - 1
DP  - 2010 Jan 15
TI  - No parietal cell hypertrophy of the metaplastic corpus mucosa in the distal 
      esophagus under PPI treatment.
PG  - 51-2
LID - 10.1016/j.prp.2009.07.007 [doi]
AB  - When biopsies obtained from short tongues of columnar epithelium in the distal 
      esophagus show only corpus or cardia-corpus transitional mucosa, it remains 
      uncertain whether we are dealing with columnar epithelium metaplasia or a 
      sampling error. In 50 patients with gastro-esophageal reflux disease receiving 
      proton pump inhibitor (PPI) with such tongues of columnar epithelium, we noted 
      that under this treatment, PPI-typical hypertrophy of the parietal cells in the 
      corpus can be found, but not in the corpus or cardia/corpus transitional mucosa 
      in biopsy material obtained from tongues of columnar epithelium in the distal 
      esophagus. These observations may by an indication that in short segments of 
      columnar epithelium corpus, mucosa with no PPI-induced hyperplasia of the 
      parietal cells may be interpreted as metaplastic mucosa.
CI  - Copyright 2009. Published by Elsevier GmbH.
FAU - Stolte, Manfred
AU  - Stolte M
AD  - Institut fur Pathologie, Klinikum Kulmbach, Albert-Schweitzer-Str. 10, 95326 
      Kulmbach, Germany. prof.m.stolte@t-online.de
LA  - eng
PT  - Journal Article
DEP - 20090806
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Biopsy
MH  - Cell Enlargement
MH  - Esophagus/*pathology
MH  - Gastroesophageal Reflux/*drug therapy/*pathology
MH  - Humans
MH  - Metaplasia/pathology
MH  - Parietal Cells, Gastric/*pathology
MH  - Proton Pump Inhibitors/*therapeutic use
EDAT- 2009/08/12 09:00
MHDA- 2010/05/04 06:00
CRDT- 2009/08/12 09:00
PHST- 2009/03/16 00:00 [received]
PHST- 2009/07/01 00:00 [accepted]
PHST- 2009/08/12 09:00 [entrez]
PHST- 2009/08/12 09:00 [pubmed]
PHST- 2010/05/04 06:00 [medline]
AID - S0344-0338(09)00204-0 [pii]
AID - 10.1016/j.prp.2009.07.007 [doi]
PST - ppublish
SO  - Pathol Res Pract. 2010 Jan 15;206(1):51-2. doi: 10.1016/j.prp.2009.07.007. Epub 
      2009 Aug 6.