PMID- 19665072
OWN - NLM
STAT- MEDLINE
DCOM- 20090901
LR  - 20090811
IS  - 1873-4456 (Electronic)
IS  - 0165-4608 (Linking)
VI  - 193
IP  - 2
DP  - 2009 Sep
TI  - A NUP98-positive acute myeloid leukemia with a t(11;12)(p15;q13) without HOXC 
      cluster gene involvement.
PG  - 109-11
LID - 10.1016/j.cancergencyto.2009.04.015 [doi]
AB  - We report a case of adult acute myeloid leukemia with a new t(11;12)(p15;q13) 
      underlying a NUP98 rearrangement without HOXC cluster gene involvement. We 
      designed a specific double-color double-fusion FISH assay to discriminate between 
      this t(11;12)(p15;q13) and those producing NUP98-HOXC11 or NUP98-HOXC13. Our 
      fluorescence in situ hybridization (FISH) showed that putative candidate partners 
      mapping 600 kilobases centromeric to HOXC were RARG (retinoic acid receptor 
      gamma), MFSD5 (major facilitator superfamily domain containing 5), and ESPL1 
      (extra spindle pole bodies homolog 1). It is noteworthy that so far only ESPL1 
      has been implicated in human cancers. This FISH assay is useful for diagnostic 
      screening of NUP98-positive leukemias.
FAU - La Starza, Roberta
AU  - La Starza R
AD  - Hematology and Bone Marrow Transplantation Unit, University of Perugia, 
      Ematologia e Trapianto di Midollo Osseo, Ospedale S.M. della Misericordia, 
      (Padiglione B, piano -2), S. Andrea delle Fratte, 06156 Perugia, Italy.
FAU - Brandimarte, Lucia
AU  - Brandimarte L
FAU - Pierini, Valentina
AU  - Pierini V
FAU - Nofrini, Valeria
AU  - Nofrini V
FAU - Gorello, Paolo
AU  - Gorello P
FAU - Crescenzi, Barbara
AU  - Crescenzi B
FAU - Berchicci, Laura
AU  - Berchicci L
FAU - Matteucci, Caterina
AU  - Matteucci C
FAU - Romoli, Silvia
AU  - Romoli S
FAU - Beacci, Donatella
AU  - Beacci D
FAU - Rosati, Roberto
AU  - Rosati R
FAU - Martelli, Massimo F
AU  - Martelli MF
FAU - Mecucci, Cristina
AU  - Mecucci C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Nuclear Pore Complex Proteins)
RN  - 0 (Nup98 protein, human)
SB  - IM
MH  - Adult
MH  - *Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 12
MH  - Female
MH  - *Genes, Homeobox
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Multigene Family
MH  - Nuclear Pore Complex Proteins/*genetics
MH  - *Translocation, Genetic
EDAT- 2009/08/12 09:00
MHDA- 2009/09/02 06:00
CRDT- 2009/08/12 09:00
PHST- 2009/02/26 00:00 [received]
PHST- 2009/04/03 00:00 [accepted]
PHST- 2009/08/12 09:00 [entrez]
PHST- 2009/08/12 09:00 [pubmed]
PHST- 2009/09/02 06:00 [medline]
AID - S0165-4608(09)00235-0 [pii]
AID - 10.1016/j.cancergencyto.2009.04.015 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2009 Sep;193(2):109-11. doi: 
      10.1016/j.cancergencyto.2009.04.015.