PMID- 19668598
OWN - NLM
STAT- MEDLINE
DCOM- 20091027
LR  - 20221207
IS  - 1090-0535 (Electronic)
IS  - 1090-0535 (Linking)
VI  - 15
DP  - 2009 Aug 8
TI  - Monocyte chemoattractant protein (MCP)-1 -2518 A/G SNP in Chinese Han patients 
      with VKH syndrome.
PG  - 1537-41
AB  - PURPOSE: Vogt-Koyanagi-Harada (VKH) syndrome is an autoimmune disease. The 
      monocyte chemoattractant protein-1 (MCP-1) gene has been implicated in the 
      pathogenesis of certain autoimmune diseases. The aim of this study was to examine 
      whether a MCP-1 polymorphism was associated with VKH syndrome. METHODS: A 
      case-control analysis was performed using genomic DNA samples from 307 VKH 
      patients and 319 age-, sex-, and ethnically-matched healthy controls. The MCP-1 
      polymorphism at the -2518 A/G locus was genotyped using polymerase chain reaction 
      restriction fragment length polymorphism (PCR-RFLP) assay. RESULTS: The 
      distribution of genotypic frequency of the MCP-1 -2518 A/G polymorphism in all 
      subjects did not deviate from Hardy-Weinberg equilibrium (HWE; p>0.05). Allelic 
      and genotypic frequency analysis revealed no significant difference between VKH 
      patients and healthy controls for the MCP-1 -2518 A/G polymorphism (p>0.05). No 
      significant differences were found according to gender and neither was found 
      according to extraocular findings including neck stiffness, tinnitus, alopecia, 
      poliosis, dysacusia, scalp hypersensitivity, and vitiligo. CONCLUSIONS: The 
      result suggests that the susceptibility to VKH syndrome in Chinese Han patients 
      may be not influenced by the MCP-1 -2518 A/G polymorphism.
FAU - Hou, Shengping
AU  - Hou S
AD  - The First Affiliated Hospital, Chongqing Medical University, Chongqing Key 
      Laboratory of Ophthalmology, and Chongqing Eye Institute, Chongqing, P.R. China.
FAU - Yang, Peizeng
AU  - Yang P
FAU - Xie, Lin
AU  - Xie L
FAU - Du, Liping
AU  - Du L
FAU - Zhou, Hongyan
AU  - Zhou H
FAU - Jiang, Zhengxuan
AU  - Jiang Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090808
PL  - United States
TA  - Mol Vis
JT  - Molecular vision
JID - 9605351
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Uveomeningoencephalitic Syndrome/*genetics
PMC - PMC2722713
EDAT- 2009/08/12 09:00
MHDA- 2009/10/29 06:00
PMCR- 2009/01/01
CRDT- 2009/08/12 09:00
PHST- 2009/07/08 00:00 [received]
PHST- 2009/08/05 00:00 [accepted]
PHST- 2009/08/12 09:00 [entrez]
PHST- 2009/08/12 09:00 [pubmed]
PHST- 2009/10/29 06:00 [medline]
PHST- 2009/01/01 00:00 [pmc-release]
AID - 164 [pii]
AID - 2009MOLVIS0236 [pii]
PST - epublish
SO  - Mol Vis. 2009 Aug 8;15:1537-41.