PMID- 19669321
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1936-0533 (Print)
IS  - 1936-0541 (Electronic)
IS  - 1936-0533 (Linking)
VI  - 2
IP  - 4
DP  - 2008 Dec
TI  - A 7-day profile of oxidative stress and antioxidant status in patients with acute 
      liver failure.
PG  - 465-70
LID - 10.1007/s12072-008-9098-6 [doi]
AB  - PURPOSE: Acute liver failure (ALF) is characterized by a rapid and massive 
      destruction of hepatocytes. The role of oxidative stress in perpetuating the 
      injury is undefined and may be a potential therapeutic target. Our aim was to 
      study serial variation in oxidative stress and antioxidant status in patients 
      with ALF. METHODS: The study involved a prospective case-control study set in a 
      tertiary care referral center. Thirty-two consecutive patients admitted with ALF 
      were included with 23 healthy controls for comparison. Level of systemic 
      oxidative stress as defined by superoxide dismutase (SOD), lipid peroxidation 
      products (thiobarbituric acid reactive derivatives [TBARS]), and the total 
      antioxidant capacity as the ferric reducing ability of plasma (FRAP) was measured 
      at baseline on days 3 and 7. RESULTS: The patients were aged 24 years (range 
      13-60 years) and included 20 females. Thirteen (40.6%) patients died. Patients 
      with ALF had significantly increased systemic oxidative stress at presentation, 
      as reflected by higher levels of SOD (P < 0.001) and TBARS (P < 0.001) than 
      controls. Both TBARS levels and FRAP decreased progressively from admission to 
      the end of first week among the survivors (P = 0.004 and 0.015, respectively). 
      The antioxidant status reflected by FRAP (P = 0.001) was significantly lower in 
      ALF patients than controls. No relation was found between the level of oxidative 
      stress and the mortality or complications. CONCLUSION: A high level of systemic 
      oxidative stress exists in ALF, with depletion of antioxidant reserves. Further 
      studies are needed to define the clinical correlation of the large pro-oxidant 
      burden.
FAU - Bhatia, Vikram
AU  - Bhatia V
AD  - Department of Gastroenterology and Human Nutrition, All India Institute of 
      Medical Sciences, New Delhi, 110029, India.
FAU - Bhardwaj, Payal
AU  - Bhardwaj P
FAU - Elikkottil, Jessina
AU  - Elikkottil J
FAU - Batra, Jyoti
AU  - Batra J
FAU - Saraya, Anoop
AU  - Saraya A
LA  - eng
PT  - Journal Article
DEP - 20080916
PL  - United States
TA  - Hepatol Int
JT  - Hepatology international
JID - 101304009
PMC - PMC2716903
EDAT- 2009/08/12 09:00
MHDA- 2009/08/12 09:01
PMCR- 2008/12/01
CRDT- 2009/08/12 09:00
PHST- 2007/12/28 00:00 [received]
PHST- 2008/08/12 00:00 [accepted]
PHST- 2009/08/12 09:00 [entrez]
PHST- 2009/08/12 09:00 [pubmed]
PHST- 2009/08/12 09:01 [medline]
PHST- 2008/12/01 00:00 [pmc-release]
AID - 9098 [pii]
AID - 10.1007/s12072-008-9098-6 [doi]
PST - ppublish
SO  - Hepatol Int. 2008 Dec;2(4):465-70. doi: 10.1007/s12072-008-9098-6. Epub 2008 Sep 
      16.