PMID- 19669395
OWN - NLM
STAT- MEDLINE
DCOM- 20100809
LR  - 20211020
IS  - 1573-2576 (Electronic)
IS  - 0360-3997 (Linking)
VI  - 32
IP  - 6
DP  - 2009 Dec
TI  - Expression of renin-angiotensin system on dendritic cells of patients with 
      coronary artery disease.
PG  - 347-56
LID - 10.1007/s10753-009-9141-3 [doi]
AB  - Dendritic cells (DCs) and renin-angiotensin system (RAS) have both been reported 
      to contribute to the pathogenesis of atherosclerosis. Recently researches find 
      the RAS expression on DCs and its effect on DCs' differentiation and 
      proinflammatory function. The pattern of RAS expression on DCs derived from 
      normal monocytes vs that on DCs derived from cornoary artery diease was 
      investigated. In 82 coronary artery disease (CAD) patients and healthy controls 
      (CTL), expressions of angiotensin I-converting enzyme (ACE), angiotensin AT1 
      receptor and DC-specific ICAM-3-grabbing nonintegrin (DC-SIGN) on DCs were 
      measured by western-blot: CAD patients had an increased expression of ACE, AT1 
      receptor and DC-SIGN compared to controls especially in acute myocardial 
      infarction (AMI). Cardiovascular risk factors of cardiovascular disease and 
      circulating anigotensin II (Ang II) were assessed and found increased in AMI 
      compared with CTL. The DC-SIGN and high-sensitivity C-reactive protein (hsCRP) 
      also had significant correlations with RAS expression on DCs. Our research 
      demonstrated the RAS expressions on DCs and their increase in CAD especially AMI. 
      The RAS activation on DCs may cause a series of changes such as enhancing 
      recruitment of DCs, activating the T cells and increasing their proinflammtory 
      functions. The recruitment and T cells contact ability of DCs increases through 
      DC-SIGN may be one of pathogenesis of atherosclerosis and this function may 
      promoted by tissue RAS. CRP may also have some effect to the local RAS exprssion 
      on DCs.
FAU - Sun, Peiyu
AU  - Sun P
AD  - Department of Cardiology, School of Medicine, the First Affiliated Hospital of 
      Zhejiang University, No 79, Qin chun Road, Hangzhou 310003, Zhejiang Province, 
      China.
FAU - Zhang, Wei
AU  - Zhang W
FAU - Zhu, Weiguo
AU  - Zhu W
FAU - Yan, Hui
AU  - Yan H
FAU - Zhu, Jianhua
AU  - Zhu J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Inflammation
JT  - Inflammation
JID - 7600105
SB  - IM
MH  - Aged
MH  - Cells, Cultured
MH  - Coronary Artery Disease/genetics/*immunology/*pathology/physiopathology
MH  - Dendritic Cells/*immunology/metabolism/*pathology
MH  - Female
MH  - Gene Expression Regulation/*immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Renin-Angiotensin System/*genetics/immunology
EDAT- 2009/08/12 09:00
MHDA- 2010/08/10 06:00
CRDT- 2009/08/12 09:00
PHST- 2009/08/12 09:00 [entrez]
PHST- 2009/08/12 09:00 [pubmed]
PHST- 2010/08/10 06:00 [medline]
AID - 10.1007/s10753-009-9141-3 [doi]
PST - ppublish
SO  - Inflammation. 2009 Dec;32(6):347-56. doi: 10.1007/s10753-009-9141-3.