PMID- 19670087
OWN - NLM
STAT- MEDLINE
DCOM- 20100614
LR  - 20100311
IS  - 1814-1412 (Electronic)
IS  - 1562-2975 (Linking)
VI  - 11
IP  - 2 Pt 2
DP  - 2010 Mar
TI  - Anatomical and functional correlates in major depressive disorder: the 
      contribution of neuroimaging studies.
PG  - 165-80
LID - 10.1080/15622970903131571 [doi]
AB  - Several studies suggested the neural networks modulating aspects of emotional 
      behaviour to be implicated in the pathophysiology of mood disorders. These 
      networks involve the medial prefrontal cortex (MPFC) and closely related areas in 
      the medial and caudolateral orbital cortex (medial prefrontal network), amygdala, 
      hippocampus, and ventromedial parts of the basal ganglia, where alterations in 
      grey matter volume and neurophysiological activity are found in cases with 
      recurrent depressive episodes. Such findings hold major implications for models 
      of the neurocircuits that underlie depression. In particular, evidence from 
      lesion analysis studies suggests that MPFC and related limbic and 
      striato-pallido-thalamic structures organize emotional expression. The aim of 
      this paper is to review the contribution of the most relevant studies with single 
      photon emission tomography (SPECT), positron emission tomography (PET) and 
      magnetic resonance imaging (MRI) to the understanding of pathophysiology of major 
      depressive disorder (MDD), with particular focus on the reversibility of 
      functional correlates with treatment.
FAU - Rigucci, Silvia
AU  - Rigucci S
AD  - Department of Psychiatry, II Faculty of Medicine, Sant'Andrea Hospital, Sapienza 
      University of Rome, Rome, Italy. s.rigucci@hotmail.it
FAU - Serafini, Gianluca
AU  - Serafini G
FAU - Pompili, Maurizio
AU  - Pompili M
FAU - Kotzalidis, Giorgio D
AU  - Kotzalidis GD
FAU - Tatarelli, Roberto
AU  - Tatarelli R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - World J Biol Psychiatry
JT  - The world journal of biological psychiatry : the official journal of the World 
      Federation of Societies of Biological Psychiatry
JID - 101120023
RN  - 0 (Antidepressive Agents)
SB  - IM
MH  - Antidepressive Agents/pharmacology
MH  - Brain/drug effects/pathology/physiopathology
MH  - Depressive Disorder, Major/drug therapy/*pathology/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Mood Disorders/pathology/physiopathology
MH  - Positron-Emission Tomography
MH  - Tomography, Emission-Computed, Single-Photon
RF  - 100
EDAT- 2009/08/12 09:00
MHDA- 2010/06/15 06:00
CRDT- 2009/08/12 09:00
PHST- 2009/08/12 09:00 [entrez]
PHST- 2009/08/12 09:00 [pubmed]
PHST- 2010/06/15 06:00 [medline]
AID - 913776472 [pii]
AID - 10.1080/15622970903131571 [doi]
PST - ppublish
SO  - World J Biol Psychiatry. 2010 Mar;11(2 Pt 2):165-80. doi: 
      10.1080/15622970903131571.