PMID- 19670620
OWN - NLM
STAT- MEDLINE
DCOM- 20110609
LR  - 20090812
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 23
IP  - 9
DP  - 2009 May
TI  - [The expressions and correlation of AQP1 and VEGF in laryngeal squamous cell 
      carcinoma].
PG  - 407-10
AB  - OBJECTIVE: To study the expression and biological value of AQP1 and VEGF in 
      laryngeal squamous cell carcinoma (LSCC) and their correlation. METHOD: The 
      expressions of AQP1 and VEGF were detected with immunohistochemical SP method in 
      60 cases of LSCC, 22 cases of polyps of vocal cord and 30 cases of normal 
      tissues. RESULT: The expression of AQP1 and VEGF in the laryngeal carcinoma group 
      was significantly higher than that in polyps of vocal cord group and normal 
      control. The expression of AQP1 and VEGF was related to the clinical staging, the 
      differentiation degree and the lymph node metastasis. The higher was the tumor 
      stage, the stronger was AQP1 and VEGF expression; the lower was the tumor 
      differentiation, the stronger was AQP1 and VEGF expression. The expression of 
      AQP1 and VEGF in the group with lymph node metastasis was higher than that in non 
      metastasis ones; The sexuality and age did not affect the expressions of AQP1 and 
      VEGF. The expressions was direct correlation between AQP1 and VEGF in the 
      laryngeal carcinoma tissues. CONCLUSION: The high expressions of AQP1 and VEGF 
      and the close relationship with the clinical pathological factors in the LSCC, 
      implicated that AQP1 and VEGF played an important role in the laryngeal carcinoma 
      cells growth,metastasis and angiogenesis of LSCC.
FAU - Gao, Xiaowei
AU  - Gao X
AD  - Department of Otorhinolaryngology, the Second Hospital of Tianjin Medical 
      University, Tianjin, China. beny51@126.com
FAU - Huang, Yongwrang
AU  - Huang Y
FAU - Liu, Jing
AU  - Liu J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (AQP1 protein, human)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 146410-94-8 (Aquaporin 1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aquaporin 1/*metabolism
MH  - Carcinoma, Squamous Cell/blood supply/*metabolism/pathology
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/blood supply/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Vascular Endothelial Growth Factor A/*metabolism
EDAT- 2009/08/13 09:00
MHDA- 2011/06/10 06:00
CRDT- 2009/08/13 09:00
PHST- 2009/08/13 09:00 [entrez]
PHST- 2009/08/13 09:00 [pubmed]
PHST- 2011/06/10 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 May;23(9):407-10.