PMID- 19671026
OWN - NLM
STAT- MEDLINE
DCOM- 20091203
LR  - 20090812
IS  - 1744-8328 (Electronic)
IS  - 1473-7140 (Linking)
VI  - 9
IP  - 8
DP  - 2009 Aug
TI  - Therapeutic potential of dendritic cell vaccines in sarcoma of the extremities.
PG  - 1065-71
LID - 10.1586/era.09.78 [doi]
AB  - Sarcomas of the extremities are challenging to treat. They are divided into 
      soft-tissue and bone sarcomas in general, which also have many subtypes, based on 
      their different mesenchymal origins and anatomical locations, respectively. Each 
      of these sarcomas present in different ways, exhibit different behaviors and 
      prognoses, and present unique therapeutic challenges. Dendritic cells (DCs) are 
      the best professional antigen-presenting cells that can induce both the 
      generation and proliferation of specific cytotoxic T lymphocytes and helper T 
      lymphocytes through antigen presentation by MHC class I and class II molecules, 
      respectively. In this review, a series of recently conducted immunotherapy for 
      extremital sarcomas based on DCs are summarized and the potential for therapeutic 
      DC vaccination targeted against these tumors is assessed.
FAU - Yu, Zhe
AU  - Yu Z
AD  - Center of Orthopedic Surgery, Orthopedics Oncology Institute of Chinese PLA, 
      Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, P.R. China. 
      yuzhe780519@yahoo.com.cn
FAU - Ren, Pengcheng
AU  - Ren P
FAU - Zhang, Xudong
AU  - Zhang X
FAU - Zhang, Ting
AU  - Zhang T
FAU - Ma, Bao'an
AU  - Ma B
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Expert Rev Anticancer Ther
JT  - Expert review of anticancer therapy
JID - 101123358
RN  - 0 (Cancer Vaccines)
SB  - IM
MH  - Animals
MH  - Cancer Vaccines/immunology/*therapeutic use
MH  - Cell Proliferation
MH  - Clinical Trials as Topic
MH  - Dendritic Cells/*immunology
MH  - Extremities/pathology
MH  - Humans
MH  - Immunotherapy/methods
MH  - Sarcoma/immunology/*therapy
MH  - T-Lymphocytes, Cytotoxic/immunology
MH  - T-Lymphocytes, Helper-Inducer/immunology
RF  - 38
EDAT- 2009/08/13 09:00
MHDA- 2009/12/16 06:00
CRDT- 2009/08/13 09:00
PHST- 2009/08/13 09:00 [entrez]
PHST- 2009/08/13 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - 10.1586/era.09.78 [doi]
PST - ppublish
SO  - Expert Rev Anticancer Ther. 2009 Aug;9(8):1065-71. doi: 10.1586/era.09.78.