PMID- 19671306
OWN - NLM
STAT- MEDLINE
DCOM- 20091110
LR  - 20201209
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 89
IP  - 14
DP  - 2009 Apr 14
TI  - [Effects of Helicobacter pylori on blood glucose fluctuation in type 2 diabetic 
      patients].
PG  - 958-61
AB  - OBJECTIVE: To investigate the effects of Helicobacter pylori (Hp) on blood 
      glucose fluctuation in type 2 diabetic mellitus. METHODS: 130 type 2 diabetic 
      patients were selected, 72 patients with Hp infection and 58 without Hp 
      infection. Relevant clinical data: blood pressure, body mass index, cholesterol, 
      triglyceride, low density lipoprotein cholesterol, high density lipoprotein 
      cholesterol, glycosylated hemoglobin, insulin resistance index, liver function, 
      and renal function were collected. The data of blood glucose levels at 7 time 
      points, 6 - 7 am, 9 - 10 am, 11 - 12 am, 14 - 15 pm, 17 - 18 pm, 19 - 20 pm, and 
      22 - 23 pm in 3 days, totally 21 data, were collected. And input into the OTDMS 
      data analysis software to evaluate the blood glucose fluctuation indexes: 
      standard deviation of mean blood glucose (SDBG), mean amplitude of glycemic 
      excursions (MAGE), large amplitude of glycemic excursions (LAGE). RESULTS: There 
      were no significant differences in age, course of disease, blood pressure, body 
      mass index, cholesterol, triglyceride, low density lipoprotein cholesterol, 
      glycosylated hemoglobin, and insulin resistance index between these 2 groups (all 
      P > 0.05). The levels of MBG, SDBG, MAGE, LAGE, (mmol/L: 9.0 +/- 1.1 vs 7.6 +/- 
      0.5, 3.3 +/- 1.1 vs 1.7 +/- 0.5, 6.7 +/- 4.5 vs 3.0 +/- 1.1, 8.6 +/- 3.8 vs 4.2 
      +/- 1.5, all P < 0.05) and incidence of hypoglycemia [16.6% (12/72) vs 5.1% 
      (3/58), P < 0.05] were all higher in the Hp positive group than in the Hp 
      negative group. CONCLUSION: Hp infection has a significant effect on the daily 
      blood glucose level and blood glucose fluctuation in the patients with type 2 
      diabetes.
FAU - Wang, Shao-zhen
AU  - Wang SZ
AD  - Key Laboratory of Hormones and Development of Ministry of Health and Tianjin, 
      Department of Diabetic Gastroenterology, Metabolic Disease Hospital, Tianjin 
      Medical University, Tianjin 300070, China. shaozhenw@eyou.com
FAU - Shi, Ya-nan
AU  - Shi YN
FAU - Zhao, Jing
AU  - Zhao J
FAU - Wang, Zhi-da
AU  - Wang ZD
LA  - chi
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Type 2/*blood/*microbiology
MH  - Female
MH  - Helicobacter Infections/*metabolism
MH  - Helicobacter pylori/physiology
MH  - Humans
MH  - Retrospective Studies
EDAT- 2009/08/13 09:00
MHDA- 2009/11/11 06:00
CRDT- 2009/08/13 09:00
PHST- 2009/08/13 09:00 [entrez]
PHST- 2009/08/13 09:00 [pubmed]
PHST- 2009/11/11 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2009 Apr 14;89(14):958-61.