PMID- 19671335
OWN - NLM
STAT- MEDLINE
DCOM- 20091117
LR  - 20201209
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 89
IP  - 20
DP  - 2009 May 26
TI  - [Clinical observation of heparin-induced thrombocytopenia].
PG  - 1405-7
AB  - OBJECTIVE: To explore the treatment of heparin-induced thrombocytopenia (HIT) in 
      venous thromboembolism. METHODS: A total of 202 patients with venous 
      thromboembolism without anticoagulation contraindications were enrolled. All of 
      them were treated with low molecular weight heparin (LMWH) and/or unfractionated 
      heparin (UFH). The peripheral blood cells were examined regularly. RESULTS: HIT 
      occurred in 6 patients. And argatroban was used to treat HIT. The overall 
      incidence rate of HIT in this study was 2.97%. The time of occurrence of HIT was 
      about Days 3 - 9 after using heparin. The platelet recovered to the basic level 
      at Days 3 - 7 after withdrawing heparin and initiating argatroban. CONCLUSION: 
      The count of platelet should be measured in the patients receiving regular LMWH 
      and/or UFH therapy. And the above regimen should be discontinued timely when the 
      platelet count declined progressively by over 50%. Argatroban was effective.
FAU - Tian, Hong-yan
AU  - Tian HY
AD  - Department of Cardiology and Peripheral Vascular Diseases, First Affiliated 
      Hospital of Medical College of Xi'an Jiaotong University, Xi'an, 710061, China. 
      tianhhyy@mail.xjtu.edu.cn
FAU - Meng, Yan
AU  - Meng Y
FAU - Zhang, Jun-bo
AU  - Zhang JB
FAU - Ma, Qiang
AU  - Ma Q
FAU - Cheng, Ge-sheng
AU  - Cheng GS
FAU - Fan, Fen-ling
AU  - Fan FL
FAU - Wang, Jun
AU  - Wang J
FAU - Wan, Hong-mei
AU  - Wan HM
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Anticoagulants)
RN  - 0 (Pipecolic Acids)
RN  - 0 (Sulfonamides)
RN  - 9005-49-6 (Heparin)
RN  - 94ZLA3W45F (Arginine)
RN  - IY90U61Z3S (argatroban)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anticoagulants/*adverse effects/therapeutic use
MH  - Arginine/analogs & derivatives
MH  - Female
MH  - Heparin/*adverse effects/therapeutic use
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pipecolic Acids/therapeutic use
MH  - Platelet Count
MH  - Sulfonamides
MH  - Thrombocytopenia/*chemically induced/drug therapy
MH  - Venous Thromboembolism/drug therapy
MH  - Young Adult
EDAT- 2009/08/13 09:00
MHDA- 2009/11/18 06:00
CRDT- 2009/08/13 09:00
PHST- 2009/08/13 09:00 [entrez]
PHST- 2009/08/13 09:00 [pubmed]
PHST- 2009/11/18 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2009 May 26;89(20):1405-7.