PMID- 19671351
OWN - NLM
STAT- MEDLINE
DCOM- 20100107
LR  - 20111017
IS  - 0253-3758 (Print)
IS  - 0253-3758 (Linking)
VI  - 37
IP  - 1
DP  - 2009 Jan
TI  - [Increased postprocedural neutrophil count is an independent predictive factor of 
      poor prognosis in acute ST elevation myocardial infarction patients treated with 
      percutaneous coronary intervention].
PG  - 44-8
AB  - OBJECTIVE: The aim of the study was to evaluate the prognostic value of the 
      postprocedural neutrophil count in patients with first acute ST elevation 
      myocardial infarction (STEMI) treated with successful primary percutaneous 
      coronary intervention (PCI). METHODS: A total of 226 consecutive STEMI patients 
      underwent successful primary PCI were enrolled. Electrocardiograms were recorded 
      before PCI and 2 hours after PCI. Neutrophil counts were measured within 12 hours 
      after PCI. All patients were followed up for 2 years. Logistic regression 
      analysis was used to evaluate predictive values of postprocedural neutrophil for 
      ST-segment resolution (STR) after PCI and for death, non-fatal myocardial 
      infarction and heart failure at 30 days and 2 years post PCI. Time-to-event 
      analyses were performed using the Kaplan-Meier survival curves in patients with 
      various ranges of postprocedural neutrophil counts. RESULTS: Postprocedural 
      neutrophil count ranged from 2.83x10(9)/L to 18.74x10(9)/L, first quartile, 
      median and fourth quartile were 5.66x10(9)/L, 7.38x10(9)/L and 9.34x10(9)/L 
      respectively. Multivariable logistic analysis showed that when postprocedural 
      neutrophil count increased 1x10(9)/L, the risk of non-STR increased 2.28 fold 
      (OR: 2.28, P=0.009), the risk of death (OR: 1.63, P=0.010) and heart failure (OR: 
      1.16, P=0.035) at 30 days increased 1.63 and 1.16 folds respectively, and the 
      risk of death (OR: 1.29, P=0.003) and heart failure (OR: 1.20, P=0.007) at 2 
      years increased 1.29 and 1.20 folds respectively, but the risk of non-fatal 
      myocardial infarction was not affected by postprocedural neutrophil count. 
      Furthermore, the patients with postprocedural neutrophil count>or=9.34x10(9)/L 
      had significant lower 30-day (89.1% vs. 99.1% vs. 98.2%, P=0.010) and 2-year 
      (82.4% vs. 96.1% vs. 96.3%, P=0.003) survival rates compared with the patients 
      with postprocedural neutrophil count from 5.66x10(9)/L to 9.33x10(9)/L and the 
      patients with postprocedural neutrophil count<5.66x10(9)/L (all P<0.05). 
      CONCLUSION: Postprocedural neutrophil count is an independent predictor of short- 
      and long-term death and heart failure in first acute STEMI patients treated with 
      successful primary PCI.
FAU - He, Rong
AU  - He R
AD  - Department of Cardiology, Third Hospital, Peking University, Beijing 100191, 
      China.
FAU - Yang, Zhen-hua
AU  - Yang ZH
FAU - Li, Hai-yan
AU  - Li HY
FAU - Guo, Li-jun
AU  - Guo LJ
FAU - Zhang, Fu-chun
AU  - Zhang FC
FAU - Niu, Jie
AU  - Niu J
FAU - Zhang, Yong-zhen
AU  - Zhang YZ
FAU - Wang, Gui-song
AU  - Wang GS
FAU - Gao, Wei
AU  - Gao W
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Xin Xue Guan Bing Za Zhi
JT  - Zhonghua xin xue guan bing za zhi
JID - 7910682
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Angioplasty, Balloon, Coronary/*adverse effects
MH  - Emergency Treatment/*adverse effects
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Leukocyte Count
MH  - *Leukocytosis
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/blood/*diagnosis/therapy
MH  - *Neutrophils
MH  - Prognosis
EDAT- 2009/08/13 09:00
MHDA- 2010/01/08 06:00
CRDT- 2009/08/13 09:00
PHST- 2009/08/13 09:00 [entrez]
PHST- 2009/08/13 09:00 [pubmed]
PHST- 2010/01/08 06:00 [medline]
PST - ppublish
SO  - Zhonghua Xin Xue Guan Bing Za Zhi. 2009 Jan;37(1):44-8.