PMID- 19672091
OWN - NLM
STAT- MEDLINE
DCOM- 20091228
LR  - 20091209
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 151
IP  - 1
DP  - 2010
TI  - The immunoglobulin E-Toll-like receptor network.
PG  - 1-7
LID - 10.1159/000232565 [doi]
AB  - Allergens and microbial antigens impact on effector cells and antigen-presenting 
      cells in allergic diseases. Allergens bind specifically to immunoglobulin E (IgE) 
      linked to the high-affinity receptor for IgE (FcepsilonRI) and stimulate a 
      cascade of cellular events. This leads to the release of mediators of allergic 
      reactions by effector cells on the one hand and antigen uptake, presentation and 
      T cell priming by antigen-presenting cells on the other hand. In contrast, 
      microbial antigens are recognized by pattern-recognition receptors (PRRs) of the 
      innate immune system, to which Toll-like receptors (TLRs) belong. In view of the 
      high number of microbial antigens, allergens and other soluble ligands in the 
      cellular microenvironment in vivo, it is very likely that not only separate, but 
      also concomitant stimulation of both receptor types, i.e. FcepsilonRI and TLRs, 
      occurs frequently under physiological conditions and in particular in the context 
      of allergic and infectious disorders. Thus, interaction of TLRs with FcepsilonRI 
      and regulation of the IgE synthesis is of critical immunological importance, 
      since it might profoundly modify the activation state of cells and the nature of 
      the evolving immune responses. Current knowledge about the cross talk of TLRs 
      with FcepsilonRI- and IgE-related immune responses is discussed herein.
FAU - Novak, Natalija
AU  - Novak N
AD  - Department of Dermatology and Allergy, University of Bonn Medical Center, Bonn, 
      Germany. Natalija.Novak@ukb.uni-bonn.de
FAU - Bieber, Thomas
AU  - Bieber T
FAU - Peng, Wen-Ming
AU  - Peng WM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20090806
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Allergens)
RN  - 0 (Cytokines)
RN  - 0 (Receptors, IgE)
RN  - 0 (Toll-Like Receptors)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/immunology/metabolism/therapeutic use
MH  - Animals
MH  - B-Lymphocytes/*immunology/metabolism
MH  - Cytokines/immunology/metabolism
MH  - Dendritic Cells/*immunology/metabolism
MH  - Humans
MH  - Hypersensitivity/immunology/metabolism/therapy
MH  - Immunity, Innate/immunology
MH  - Immunoglobulin E/*immunology/metabolism
MH  - Immunotherapy
MH  - Mast Cells/*immunology/metabolism
MH  - Receptors, IgE/*immunology/metabolism
MH  - Toll-Like Receptors/*immunology/metabolism
RF  - 51
EDAT- 2009/08/13 09:00
MHDA- 2009/12/29 06:00
CRDT- 2009/08/13 09:00
PHST- 2009/08/13 09:00 [entrez]
PHST- 2009/08/13 09:00 [pubmed]
PHST- 2009/12/29 06:00 [medline]
AID - 000232565 [pii]
AID - 10.1159/000232565 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2010;151(1):1-7. doi: 10.1159/000232565. Epub 2009 Aug 
      6.