PMID- 19673328
OWN - NLM
STAT- MEDLINE
DCOM- 20140926
LR  - 20161018
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 29
IP  - 5
DP  - 2009 May
TI  - [Study on colonic motility and efficacy analysis in patients with slow-transit 
      constipation treated with self-formulated Xingchang Decoction].
PG  - 403-6
AB  - OBJECTIVE: To observe the clinical efficacy of self-formulated Xingchang 
      Decoction (XCD) in treating slow-transit constipation (STC) and the dynamical 
      parameters of colonic motility during XCD treatment. METHODS: One hundred and 
      eighteen patients with STC were randomly assigned to the treatment group and the 
      control group, 59 in each group. The treatment group was treated with XCD, and 
      the control group was treated with mosapride, an intestinal energetic agent. The 
      therapeutic course for both groups was 30 days. The 72-h colonic transition test 
      was conducted and the symptom scores were observed before and after treatment; 
      the adverse reaction rate and clinical efficacy were calculated after treatment; 
      and the recurrence rate in one year was followed-up. RESULTS: Symptom scores were 
      significantly improved in the treatment group after treatment, with the 
      improvement significantly superior to that in the control group (P < 0.01). The 
      cure rate and the total effective rate were 76.27% and 93.22% in the treatment 
      group respectively, while they were 47.45% and 72.87% in the control group, 
      showing significant difference between the two groups (P < 0.01). Besides, the 
      1-year recurrence rate was significantly lower (chi2 = 10.40, P = 0.001) and the 
      improvement of colonic motor function was more in the treatment group than those 
      in the control group (P < 0.01). Only low incidence (5.08% in the treatment group 
      and 8.47% in the control group) of mild gastrointestinal reactions was shown, 
      which caused no influence on the treatment. CONCLUSION: XCD could effectively 
      improve the motility of the digestive tract, and it is effective and safe for the 
      treatment of STC.
FAU - Zhang, Ling-Ling
AU  - Zhang LL
AD  - The Third Affiliated Hospital of Luohe Medical College, Henan. lhyzzll@163.com
FAU - Zhang, Jun
AU  - Zhang J
FAU - Wang, Yu-Zhong
AU  - Wang YZ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese 
      journal of integrated traditional and Western medicine
JID - 9211576
RN  - 0 (Benzamides)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Gastrointestinal Agents)
RN  - 0 (Morpholines)
RN  - I8MFJ1C0BY (mosapride)
SB  - IM
MH  - Benzamides/therapeutic use
MH  - Constipation/*drug therapy
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Gastrointestinal Agents/therapeutic use
MH  - Gastrointestinal Transit/*drug effects
MH  - Humans
MH  - Morpholines/therapeutic use
EDAT- 2009/08/14 09:00
MHDA- 2014/09/27 06:00
CRDT- 2009/08/14 09:00
PHST- 2009/08/14 09:00 [entrez]
PHST- 2009/08/14 09:00 [pubmed]
PHST- 2014/09/27 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 May;29(5):403-6.