PMID- 19673870
OWN - NLM
STAT- MEDLINE
DCOM- 20100310
LR  - 20211203
IS  - 1365-2133 (Electronic)
IS  - 0007-0963 (Linking)
VI  - 161
IP  - 5
DP  - 2009 Nov
TI  - MYC gene numerical aberrations in actinic keratosis and cutaneous squamous cell 
      carcinoma.
PG  - 1112-8
LID - 10.1111/j.1365-2133.2009.09351.x [doi]
AB  - BACKGROUND: The genetic alterations that drive the transition from actinic 
      keratoses (AKs) to cutaneous squamous cell carcinomas (SCCs) have not been 
      defined precisely. Amplification and/or overexpression of the MYC proto-oncogene 
      have been demonstrated in several human, malignant tumours including head and 
      neck SCCs. OBJECTIVES: To evaluate the presence of MYC genomic aberrations in 
      both AKs and SCCs. METHODS: Skin biopsy specimens corresponding to AKs, SCCs and 
      control samples were included in two paraffin-embedded tissue microarrays. MYC 
      cytogenetic profile was evaluated by fluorescence in situ hybridization (FISH). 
      The results obtained were compared with MYC immunohistochemical expression. 
      RESULTS: Twenty-three AKs and 30 SCCs were evaluated. MYC numerical aberrations 
      were observed in eight of 23 (35%) AKs and 19 of 30 (63%) SCCs (P = 0.05). MYC 
      numerical aberrations were more frequent in moderately to poorly differentiated 
      SCCs (77%) when compared with well-differentiated SCCs (25%; P = 0.027). A 
      significant association between copy number gains of MYC by FISH analysis and MYC 
      protein expression was demonstrated. CONCLUSIONS: MYC gains and amplifications 
      are frequent cytogenetic abnormalities in SCCs and may play a relevant role in 
      promoting SCC undifferentiation and tumoral progression.
FAU - Toll, A
AU  - Toll A
AD  - Department of Dermatology, IMIM Hospital del Mar, Pg. 08003 Barcelona, Spain. 
      93828@imas.imim.es
FAU - Salgado, R
AU  - Salgado R
FAU - Yebenes, M
AU  - Yebenes M
FAU - Martin-Ezquerra, G
AU  - Martin-Ezquerra G
FAU - Gilaberte, M
AU  - Gilaberte M
FAU - Baro, T
AU  - Baro T
FAU - Sole, F
AU  - Sole F
FAU - Alameda, F
AU  - Alameda F
FAU - Espinet, B
AU  - Espinet B
FAU - Pujol, R M
AU  - Pujol RM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090611
PL  - England
TA  - Br J Dermatol
JT  - The British journal of dermatology
JID - 0004041
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biopsy
MH  - Carcinoma, Squamous Cell/*genetics/pathology
MH  - *Chromosome Aberrations
MH  - *Disease Progression
MH  - Female
MH  - Genes, myc/*genetics
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Keratosis, Actinic/*genetics/pathology
MH  - Male
MH  - Microarray Analysis
MH  - Middle Aged
MH  - Proto-Oncogene Mas
MH  - Skin Neoplasms/*genetics/pathology
EDAT- 2009/08/14 09:00
MHDA- 2010/03/11 06:00
CRDT- 2009/08/14 09:00
PHST- 2009/08/14 09:00 [entrez]
PHST- 2009/08/14 09:00 [pubmed]
PHST- 2010/03/11 06:00 [medline]
AID - BJD9351 [pii]
AID - 10.1111/j.1365-2133.2009.09351.x [doi]
PST - ppublish
SO  - Br J Dermatol. 2009 Nov;161(5):1112-8. doi: 10.1111/j.1365-2133.2009.09351.x. 
      Epub 2009 Jun 11.