PMID- 19674494
OWN - NLM
STAT- MEDLINE
DCOM- 20100201
LR  - 20161125
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 103
IP  - 1
DP  - 2010 Jan
TI  - Intervention with fish oil, but not with docosahexaenoic acid, results in lower 
      levels of hepatic soluble epoxide hydrolase with time in apoE knockout mice.
PG  - 16-24
LID - 10.1017/S0007114509991450 [doi]
AB  - Long-chain n-3 PUFA from fish oil protect against death from CHD but mechanisms 
      are not well understood. Preliminary results indicate that fish oil may affect 
      the enzyme soluble epoxide hydrolase (sEH) and influence inflammatory pathways in 
      a time-dependent manner. In the present study male apoE knockout (Apoe-/-) mice 
      were randomised to three dietary groups receiving a high-fat high-cholesterol 
      diet supplemented with 2 % (w/w) high-oleic acid sunflower-seed (HOSF) oil, DHA 
      oil or fish oil. Livers and proximal aortas were collected on day 2 and on weeks 
      1, 2, 4 and 10 to determine hepatic sEH levels, hepatic fatty acid composition, 
      hepatic proteome and atherosclerotic plaque size in the aortic root. Intervention 
      with fish oil, but not with DHA, resulted in significantly lower levels of 
      hepatic sEH levels with time compared with HOSF oil. DHA and fish oil caused 
      differential regulation of thirty-five hepatic proteins which were mainly 
      involved in lipoprotein metabolism and oxidative stress. All mice developed 
      atherosclerosis without differences in plaque size between the three groups. Thus 
      EPA may be responsible for lowering levels of hepatic sEH and both fish oil and 
      DHA could beneficially affect lipoprotein metabolism and oxidative stress.
FAU - Mavrommatis, Yiannis
AU  - Mavrommatis Y
AD  - Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK.
FAU - Ross, Karen
AU  - Ross K
FAU - Rucklidge, Garry
AU  - Rucklidge G
FAU - Reid, Martin
AU  - Reid M
FAU - Duncan, Gary
AU  - Duncan G
FAU - Gordon, Margaret-Jane
AU  - Gordon MJ
FAU - Thies, Frank
AU  - Thies F
FAU - Sneddon, Alan
AU  - Sneddon A
FAU - de Roos, Baukje
AU  - de Roos B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090813
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Apolipoproteins E)
RN  - 0 (Cholesterol, Dietary)
RN  - 0 (DNA Primers)
RN  - 0 (Dietary Fats)
RN  - 0 (Fish Oils)
RN  - 0 (Forkhead Box Protein O3)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (FoxO3 protein, mouse)
RN  - 25167-62-8 (Docosahexaenoic Acids)
RN  - 2UMI9U37CP (Oleic Acid)
RN  - EC 3.3.2.- (Epoxide Hydrolases)
SB  - IM
MH  - Animals
MH  - Aorta, Thoracic/drug effects/enzymology
MH  - Apolipoproteins E/*deficiency
MH  - Atherosclerosis/*pathology/prevention & control
MH  - Cholesterol, Dietary/*pharmacology
MH  - DNA Primers
MH  - Dietary Fats
MH  - Docosahexaenoic Acids/administration & dosage/*pharmacology
MH  - Epoxide Hydrolases/genetics/*metabolism
MH  - Fish Oils/administration & dosage/*pharmacology
MH  - Forkhead Box Protein O3
MH  - Forkhead Transcription Factors/genetics
MH  - Liver/drug effects/*enzymology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Oleic Acid/*pharmacology
MH  - Proteomics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Seeds
MH  - Species Specificity
EDAT- 2009/08/14 09:00
MHDA- 2010/02/02 06:00
CRDT- 2009/08/14 09:00
PHST- 2009/08/14 09:00 [entrez]
PHST- 2009/08/14 09:00 [pubmed]
PHST- 2010/02/02 06:00 [medline]
AID - S0007114509991450 [pii]
AID - 10.1017/S0007114509991450 [doi]
PST - ppublish
SO  - Br J Nutr. 2010 Jan;103(1):16-24. doi: 10.1017/S0007114509991450. Epub 2009 Aug 
      13.