PMID- 19675107
OWN - NLM
STAT- MEDLINE
DCOM- 20091009
LR  - 20230318
IS  - 1938-3207 (Electronic)
IS  - 0002-9165 (Print)
IS  - 0002-9165 (Linking)
VI  - 90
IP  - 4
DP  - 2009 Oct
TI  - Differential functional magnetic resonance imaging response to food pictures in 
      successful weight-loss maintainers relative to normal-weight and obese controls.
PG  - 928-34
LID - 10.3945/ajcn.2009.27924 [doi]
AB  - BACKGROUND: Prior research indicates that successful weight-loss maintainers 
      (SWLs) work harder than people of normal weight to maintain their weight loss, 
      including greater dietary restriction of fat and higher physical activity levels. 
      However, little work to date has examined how SWLs differ biologically from 
      normal-weight (NW) and obese controls. OBJECTIVE: The objective was to compare 
      the brain responses of SWLs to food pictures with those of NW and obese controls. 
      DESIGN: Blood oxygen level-dependent responses to high- and low-energy food 
      pictures were measured in 18 NW controls, 16 obese controls, and 17 SWLs. 
      RESULTS: Group differences were identified in 4 regions, which indicated 
      significant change in activation in response to the food pictures. SWLs showed 
      greater activation in the left superior frontal region and right middle temporal 
      region than did NW and obese controls-a pattern of results confirmed in 
      exploratory voxel-wise analyses. Obese controls also showed greater activation in 
      a bilateral precentral region. CONCLUSIONS: These results suggest that SWLs show 
      greater activation in frontal regions and primary and secondary visual cortices-a 
      pattern consistent with greater inhibitory control in response to food cues and 
      greater visual attention to the food cues. A greater engagement of inhibitory 
      control regions in response to food cues as well as a greater monitoring of foods 
      may promote control of food intake and successful weight-loss maintenance.
FAU - McCaffery, Jeanne M
AU  - McCaffery JM
AD  - Miriam Hospital and Brown Medical School, Providence, RI 02903, USA. 
      jeanne_mccaffery@brown.edu
FAU - Haley, Andreana P
AU  - Haley AP
FAU - Sweet, Lawrence H
AU  - Sweet LH
FAU - Phelan, Suzanne
AU  - Phelan S
FAU - Raynor, Hollie A
AU  - Raynor HA
FAU - Del Parigi, Angelo
AU  - Del Parigi A
FAU - Cohen, Ron
AU  - Cohen R
FAU - Wing, Rena R
AU  - Wing RR
LA  - eng
GR  - R01 DK066787/DK/NIDDK NIH HHS/United States
GR  - R01 DK066787-02S2/DK/NIDDK NIH HHS/United States
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20090812
PL  - United States
TA  - Am J Clin Nutr
JT  - The American journal of clinical nutrition
JID - 0376027
RN  - S88TT14065 (Oxygen)
SB  - IM
CIN - Am J Clin Nutr. 2009 Oct;90(4):908-9. PMID: 19710190
MH  - Adult
MH  - Brain/blood supply/physiology/*physiopathology
MH  - Brain Mapping/*methods
MH  - Female
MH  - *Food
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Obesity/*physiopathology
MH  - Oxygen/blood
MH  - Reference Values
MH  - *Visual Perception
MH  - Weight Loss/*physiology
PMC - PMC2744621
EDAT- 2009/08/14 09:00
MHDA- 2009/10/10 06:00
PMCR- 2010/10/01
CRDT- 2009/08/14 09:00
PHST- 2009/08/14 09:00 [entrez]
PHST- 2009/08/14 09:00 [pubmed]
PHST- 2009/10/10 06:00 [medline]
PHST- 2010/10/01 00:00 [pmc-release]
AID - S0002-9165(23)23287-6 [pii]
AID - 27924 [pii]
AID - 10.3945/ajcn.2009.27924 [doi]
PST - ppublish
SO  - Am J Clin Nutr. 2009 Oct;90(4):928-34. doi: 10.3945/ajcn.2009.27924. Epub 2009 
      Aug 12.