PMID- 19678528
OWN - NLM
STAT- MEDLINE
DCOM- 20090925
LR  - 20191111
IS  - 0939-3889 (Print)
IS  - 0939-3889 (Linking)
VI  - 19
IP  - 2
DP  - 2009
TI  - Steep dose gradients for simultaneous integrated boost IMRT.
PG  - 129-35
AB  - Steep dose gradients between two planning target volumes (PTVs) as may be 
      required for simultaneous integrated boosts (SIB) should be an option provided by 
      IMRT algorithms. The aim was to analyse the geometry of the SIB problem and to 
      implement the results in an algorithm for IMRT segment generation denoted 
      two-step intensity modulated radiotherapy (2-Step IMRT). It was hypothesized that 
      a gap between segments directed to the inner and the outer PTV would steepen the 
      dose gradient. The mathematical relationships were derived from the individual 
      dose levels and the geometry (diameters) of the PTVs. The results generated by 
      means of 2-Step IMRT segments were equivalent or better than the segment 
      generation using a commercial IMRT planning system. The dose to both the inner 
      and the outer PTV was clearly more homogeneous and the composite objective value 
      was the lowest. The segment numbers were lower or equal--with better sparing of 
      the surrounding tissue. In summary, it was demonstrated that 2-Step IMRT was able 
      to achieve steep dose gradients for SIB constellations.
FAU - Bratengeier, Klaus
AU  - Bratengeier K
AD  - Universitat Wurzburg, Klinik und Poliklinik fur Strahlentherapie, 
      Josef-Schneider-Str. 11, D-97080 Wurzburg, Germany. 
      Bratengeie_K@klinik.uni-wuerzburg.de
FAU - Meyer, Jurgen
AU  - Meyer J
FAU - Schwab, Franz
AU  - Schwab F
FAU - Vordermark, Dirk
AU  - Vordermark D
FAU - Flentje, Michael
AU  - Flentje M
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Z Med Phys
JT  - Zeitschrift fur medizinische Physik
JID - 100886455
SB  - IM
MH  - Algorithms
MH  - Equipment Design
MH  - Humans
MH  - Neoplasms/*radiotherapy
MH  - Particle Accelerators
MH  - *Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Radiotherapy, Intensity-Modulated/*methods
EDAT- 2009/08/15 09:00
MHDA- 2009/09/26 06:00
CRDT- 2009/08/15 09:00
PHST- 2009/08/15 09:00 [entrez]
PHST- 2009/08/15 09:00 [pubmed]
PHST- 2009/09/26 06:00 [medline]
AID - 10.1016/j.zemedi.2008.07.004 [doi]
PST - ppublish
SO  - Z Med Phys. 2009;19(2):129-35. doi: 10.1016/j.zemedi.2008.07.004.