PMID- 19679201
OWN - NLM
STAT- MEDLINE
DCOM- 20100401
LR  - 20161126
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1804
IP  - 2
DP  - 2010 Feb
TI  - Structure and catalytic mechanism of the beta-carbonic anhydrases.
PG  - 362-73
LID - 10.1016/j.bbapap.2009.08.002 [doi]
AB  - The beta-carbonic anhydrases (beta-CAs) are a diverse but structurally related 
      group of zinc-metalloenzymes found in eubacteria, plant chloroplasts, red and 
      green algae, and in the Archaea. The enzyme catalyzes the rapid interconversion 
      of CO(2) and H(2)O to HCO(3)(-) and H(+), and is believed to be associated with 
      metabolic enzymes that consume or produce CO(2) or HCO(3)(-). For many organisms, 
      beta-CA is essential for growth at atmospheric concentrations of CO(2). Of the 
      five evolutionarily distinct classes of carbonic anhydrase, beta-CA is the only 
      one known to exhibit allosterism. Here we review the structure and catalytic 
      mechanism of beta-CA, including the structural basis for allosteric regulation.
CI  - Copyright 2009 Elsevier B.V. All rights reserved.
FAU - Rowlett, Roger S
AU  - Rowlett RS
AD  - Colgate University, Department of Chemistry, Hamilton, NY 13346, USA. 
      rrowlett@colgate.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20090811
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - EC 4.2.1.1 (Carbonic Anhydrases)
SB  - IM
MH  - Animals
MH  - Carbonic Anhydrases/*chemistry/classification/*metabolism
MH  - Catalysis
MH  - Humans
RF  - 77
EDAT- 2009/08/15 09:00
MHDA- 2010/04/02 06:00
CRDT- 2009/08/15 09:00
PHST- 2009/06/23 00:00 [received]
PHST- 2009/07/30 00:00 [revised]
PHST- 2009/08/02 00:00 [accepted]
PHST- 2009/08/15 09:00 [entrez]
PHST- 2009/08/15 09:00 [pubmed]
PHST- 2010/04/02 06:00 [medline]
AID - S1570-9639(09)00196-4 [pii]
AID - 10.1016/j.bbapap.2009.08.002 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2010 Feb;1804(2):362-73. doi: 10.1016/j.bbapap.2009.08.002. 
      Epub 2009 Aug 11.