PMID- 19681484
OWN - NLM
STAT- MEDLINE
DCOM- 20090910
LR  - 20151119
IS  - 0030-6657 (Print)
IS  - 0030-6657 (Linking)
VI  - 63
IP  - 2
DP  - 2009 Mar-Apr
TI  - [Prognostic significance of cyclin D1 and cyclin B expression in laryngeal 
      squamous cell carcinomas treated with radiotherapy].
PG  - 136-40
LID - 10.1016/S0030-6657(09)70094-0 [doi]
AB  - Cyclin B1 and cyclin D1 playing the role of regulatory subunits of 
      cyclin-dependent kinases responsible for progression of cell cycle are involved 
      in carcinogenesis of head and neck tumors. The aim of this study is to 
      investigate their value for predicting clinical outcome after radiotherapy of 
      laryngeal squamous cell cancer (LSCC). MATERIAL AND METHODS: The study included 
      50 patients with LSCC treated between the years 1998 and 2003 with radiotherapy. 
      Tissue samples were studied immunohistochemically for detection of cyclin B1 and 
      cyclin D1 and their expression were correlated with clinicopathological factors, 
      local tumor control and patient survival. RESULTS: Accumulation of cyclin D1 and 
      cyclin B1 were detected in 36% and 48% of tumors respectively. No relationship 
      was observed between immunostaining for analyzed proteins and clinicopathologic 
      factors. Cyclin B1 overexpression was associated with higher rate of locoregional 
      recurrence. Five-year disease free survival rate for patients with cyclin B1 
      positive tumors was 73% v. 84% for cyclin B1 negative patients (p=0.005). 
      CONCLUSION: The expression of cyclin D1 in LSCC does not seem to have a 
      prognostic significance. Overexpression of cyclin B1 may be an indicator of the 
      risk of locoregional recurrence in patient receiving radiotherapy. Thus cyclin B1 
      detected by immunohistochemistry can be useful for predicting outcome of 
      radiotherapy in patients with LSCC.
FAU - Dupla, Dorota
AU  - Dupla D
AD  - Zaklad Teleradioterapii, Dolnoslaskie Centrum Onkologii we Wroclawiu.
FAU - Fraczek, Marcin
AU  - Fraczek M
FAU - Krecicki, Tomasz
AU  - Krecicki T
FAU - Wozniak, Zbigniew
AU  - Wozniak Z
LA  - pol
PT  - English Abstract
PT  - Journal Article
TT  - Znaczenie prognostyczne ekspresji cykliny D1 i cykliny B u pacjentow z rakiem 
      krtani leczonych radioterapia.
PL  - Poland
TA  - Otolaryngol Pol
JT  - Otolaryngologia polska = The Polish otolaryngology
JID - 0404453
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CCNB1 protein, human)
RN  - 0 (Cyclin B)
RN  - 0 (Cyclin B1)
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/metabolism
MH  - Carcinoma, Squamous Cell/*metabolism/*radiotherapy
MH  - Cyclin B/*metabolism
MH  - Cyclin B1
MH  - Cyclin D1/*metabolism
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*metabolism/*radiotherapy
MH  - Male
MH  - Middle Aged
MH  - Poland
MH  - Prognosis
MH  - Retrospective Studies
EDAT- 2009/08/18 09:00
MHDA- 2009/09/11 06:00
CRDT- 2009/08/18 09:00
PHST- 2009/08/18 09:00 [entrez]
PHST- 2009/08/18 09:00 [pubmed]
PHST- 2009/09/11 06:00 [medline]
AID - S0030-6657(09)70094-0 [pii]
AID - 10.1016/S0030-6657(09)70094-0 [doi]
PST - ppublish
SO  - Otolaryngol Pol. 2009 Mar-Apr;63(2):136-40. doi: 10.1016/S0030-6657(09)70094-0.