PMID- 19682173
OWN - NLM
STAT- MEDLINE
DCOM- 20091207
LR  - 20220330
IS  - 1600-051X (Electronic)
IS  - 0303-6979 (Linking)
VI  - 36
IP  - 10
DP  - 2009 Oct
TI  - The influence of a probiotic milk drink on the development of gingivitis: a pilot 
      study.
PG  - 850-6
LID - 10.1111/j.1600-051X.2009.01459.x [doi]
AB  - AIM: The aim of this study was to determine the effect of a probiotic milk drink 
      on gingival health and the development of experimental gingivitis. MATERIAL AND 
      METHODS: Fifty volunteer students took part in a parallel-designed non-blinded 
      study. The test group drank a probiotic drink once a day; the control group did 
      not receive any product to drink. After 8 weeks, individual mechanical plaque 
      control was interrupted for 96 h. Papilla bleeding index, interproximal plaque 
      and Turesky plaque index (PI) were recorded at baseline, after 8 weeks and again 
      96 h later. At the same time points, gingival crevicular fluid had been collected 
      for analysis of polymorphonuclear elastase, myeloperoxidase (MPO) and matrix 
      metalloproteinase-3 (MMP-3). RESULTS: Interproximal PI and papillary bleeding 
      were not different between the groups. In the test group, elastase activity and 
      MMP-3 amount were significantly lower after the intake of the probiotic milk 
      drink (p<0.001 and 0.016). There was a significant increase of MPO activity in 
      the control group; both groups were different at the end of the study (p=0.014). 
      CONCLUSIONS: The data suggest a beneficial effect of the probiotic milk drink on 
      gingival inflammation.
FAU - Staab, Benedict
AU  - Staab B
AD  - Department of Conservative Dentistry and Periodontology, Medical Faculty, 
      University of Leipzig, Leipzig, Germany.
FAU - Eick, Sigrun
AU  - Eick S
FAU - Knofler, Gerhild
AU  - Knofler G
FAU - Jentsch, Holger
AU  - Jentsch H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20090812
PL  - United States
TA  - J Clin Periodontol
JT  - Journal of clinical periodontology
JID - 0425123
RN  - EC 1.11.1.7 (Peroxidase)
RN  - EC 3.4.21.37 (Leukocyte Elastase)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Animals
MH  - Dental Plaque/etiology
MH  - Dental Plaque Index
MH  - Female
MH  - Gingival Crevicular Fluid/enzymology
MH  - Gingival Hemorrhage/etiology
MH  - Gingivitis/*etiology
MH  - Humans
MH  - Leukocyte Elastase/analysis
MH  - Male
MH  - Matrix Metalloproteinase 3/analysis
MH  - *Milk
MH  - Periodontal Index
MH  - Peroxidase/analysis
MH  - Pilot Projects
MH  - Probiotics/*therapeutic use
MH  - Young Adult
EDAT- 2009/08/18 09:00
MHDA- 2009/12/16 06:00
CRDT- 2009/08/18 09:00
PHST- 2009/08/18 09:00 [entrez]
PHST- 2009/08/18 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - CPE1459 [pii]
AID - 10.1111/j.1600-051X.2009.01459.x [doi]
PST - ppublish
SO  - J Clin Periodontol. 2009 Oct;36(10):850-6. doi: 10.1111/j.1600-051X.2009.01459.x. 
      Epub 2009 Aug 12.