PMID- 19682579
OWN - NLM
STAT- MEDLINE
DCOM- 20100204
LR  - 20131121
IS  - 1878-5492 (Electronic)
IS  - 0966-3274 (Linking)
VI  - 22
IP  - 1-2
DP  - 2009 Dec
TI  - The effect of murine anti-thymocyte globulin on experimental kidney warm 
      ischemia-reperfusion injury in mice.
PG  - 44-54
LID - 10.1016/j.trim.2009.08.001 [doi]
AB  - Kidney ischemia-reperfusion injury (IRI) is an important contributor to delayed 
      graft function (DGF) and poor outcome of allografts. Small clinical studies 
      suggest a beneficial role for human anti-thymocyte globulin (ATG) in DGF. We 
      investigated the short-term effect of mouse anti-thymocyte globulin (mATG) on 
      kidney warm IRI in mice. We administered either mATG, rabbit immunoglobulin 
      (RIgG), or saline with different dosing schedules in three different IRI models: 
      30 min bilateral, 60 min bilateral, and 45min unilateral IRI. mATG effectively 
      depleted circulating T cells but had less effect on kidney-infiltrating T cells. 
      There was no difference in serum creatinine levels between groups in each study. 
      Scoring of renal tubular damage and regenerating tubules revealed no difference 
      between groups. The percentage of CD3(+)CD4(-)CD8(-) double-negative (DN) T 
      cells, which were reported to contribute to the pathogenesis of lupus nephritis, 
      increased and the percentages of regulatory T cells and NK cells decreased in the 
      post-ischemic kidneys of mATG treated mice. mATG did not alter the expression of 
      pro-inflammatory cytokines such as IFN-gamma or anti-inflammatory cytokines such 
      as IL-10 in post-ischemic kidneys. mATG treatment, whether initiated before 
      ischemia or immediately after reperfusion, had minimal effects on renal injury 
      following warm IRI in mice.
FAU - Jang, Hye Ryoun
AU  - Jang HR
AD  - Nephrology Division, Department of Medicine, Johns Hopkins University School of 
      Medicine, Baltimore, Maryland 21205, USA. shinehr@gmail.com
FAU - Gandolfo, Maria Teresa
AU  - Gandolfo MT
FAU - Ko, Gang Jee
AU  - Ko GJ
FAU - Racusen, Lorraine
AU  - Racusen L
FAU - Rabb, Hamid
AU  - Rabb H
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090812
PL  - Netherlands
TA  - Transpl Immunol
JT  - Transplant immunology
JID - 9309923
RN  - 0 (Antilymphocyte Serum)
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
RN  - 0 (Immunoglobulin G)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Animals
MH  - Antilymphocyte Serum/*therapeutic use
MH  - Blood Cell Count
MH  - Chemokines/metabolism
MH  - Creatinine/blood
MH  - Cytokines/metabolism
MH  - Immunoglobulin G/therapeutic use
MH  - Kidney/blood supply/metabolism/*pathology/physiopathology
MH  - Kidney Cortex/pathology
MH  - Kidney Medulla/pathology
MH  - Kidney Tubules/pathology
MH  - Lymphocyte Depletion
MH  - Lymphocyte Subsets/cytology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Rabbits
MH  - Reperfusion Injury/immunology/metabolism/pathology/physiopathology/*therapy
MH  - Spleen/pathology
MH  - Survival Rate
MH  - T-Lymphocytes/cytology/immunology
EDAT- 2009/08/18 09:00
MHDA- 2010/02/05 06:00
CRDT- 2009/08/18 09:00
PHST- 2009/05/11 00:00 [received]
PHST- 2009/07/23 00:00 [revised]
PHST- 2009/08/04 00:00 [accepted]
PHST- 2009/08/18 09:00 [entrez]
PHST- 2009/08/18 09:00 [pubmed]
PHST- 2010/02/05 06:00 [medline]
AID - S0966-3274(09)00082-3 [pii]
AID - 10.1016/j.trim.2009.08.001 [doi]
PST - ppublish
SO  - Transpl Immunol. 2009 Dec;22(1-2):44-54. doi: 10.1016/j.trim.2009.08.001. Epub 
      2009 Aug 12.