PMID- 19682619
OWN - NLM
STAT- MEDLINE
DCOM- 20091105
LR  - 20111117
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 27
IP  - 43
DP  - 2009 Oct 9
TI  - Hepatitis B vaccination failure in celiac disease: is there a need to reassess 
      current immunization strategies?
PG  - 6030-3
LID - 10.1016/j.vaccine.2009.07.099 [doi]
AB  - Human leukocyte antigen (HLA) phenotype DQ2 is considered the most important 
      genetic marker for un-responsiveness to hepatitis B vaccine. Since celiac disease 
      (CD) is also strongly associated with the same haplo-type it may be hypothesized 
      that celiac patients are less able to respond to the vaccine. We report a 
      retrospective study on celiac patients vaccinated with three doses of 10 microg 
      at 3, 5 and 11 months of age by an intramuscular injection of a recombinant 
      hepatitis B vaccine (Engerix B). We found 30 of 60 celiac patients (50%) 
      unresponsive to vaccination and a significant higher number of responders among 
      patients younger than 18 months at the time of celiac disease diagnosis. Our 
      study confirms that celiac patients have a lower percentage of response to 
      hepatitis B vaccination than healthy subjects. These findings provide useful 
      information to evaluate if current vaccine strategies should be reassessed and if 
      revaccination should be recommended.
FAU - Leonardi, S
AU  - Leonardi S
AD  - Broncho-Pneumology & Cystic Fibrosis Unit, Department of Pediatrics, University 
      of Catania, Catania, Italy. leonardi@unict.it
FAU - Spina, M
AU  - Spina M
FAU - Spicuzza, L
AU  - Spicuzza L
FAU - Rotolo, N
AU  - Rotolo N
FAU - La Rosa, M
AU  - La Rosa M
LA  - eng
PT  - Journal Article
DEP - 20090812
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Engerix-B)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ2 antigen)
RN  - 0 (Hepatitis Antibodies)
RN  - 0 (Hepatitis B Vaccines)
RN  - 0 (Vaccines, Synthetic)
SB  - IM
MH  - Celiac Disease/blood/genetics/*immunology
MH  - Female
MH  - HLA-DQ Antigens/genetics
MH  - Hepatitis Antibodies/*blood
MH  - Hepatitis B Vaccines/*immunology
MH  - Humans
MH  - Infant
MH  - Male
MH  - Retrospective Studies
MH  - Vaccination
MH  - Vaccines, Synthetic/immunology
EDAT- 2009/08/18 09:00
MHDA- 2009/11/06 06:00
CRDT- 2009/08/18 09:00
PHST- 2009/03/23 00:00 [received]
PHST- 2009/07/11 00:00 [revised]
PHST- 2009/07/22 00:00 [accepted]
PHST- 2009/08/18 09:00 [entrez]
PHST- 2009/08/18 09:00 [pubmed]
PHST- 2009/11/06 06:00 [medline]
AID - S0264-410X(09)01111-6 [pii]
AID - 10.1016/j.vaccine.2009.07.099 [doi]
PST - ppublish
SO  - Vaccine. 2009 Oct 9;27(43):6030-3. doi: 10.1016/j.vaccine.2009.07.099. Epub 2009 
      Aug 12.