PMID- 19683023
OWN - NLM
STAT- MEDLINE
DCOM- 20091130
LR  - 20111117
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 70
IP  - 11
DP  - 2009 Nov
TI  - Estimation of high-resolution HLA-A, -B, -C, -DRB1 allele and haplotype 
      frequencies based on 8862 German stem cell donors and implications for strategic 
      donor registry planning.
PG  - 895-902
LID - 10.1016/j.humimm.2009.08.006 [doi]
AB  - Human leukocyte antigen (HLA) haplotype frequency distributions in specific 
      populations can be applied to optimize both individual stem cell donor searches 
      and donor registry planning. We present allele and haplotype frequencies derived 
      from a data set of 8862 German stem cell donors who were typed at high resolution 
      for the HLA-A, HLA-B, HLA-C, and HLA-DRB1 genes upon registration. Calculated 
      haplotype frequencies were used to estimate the probability p to find matching 
      donors subject to donor registry size n. The impact of various matching standards 
      on p(n) was analyzed. When high-resolution matching for HLA-A, HLA-B, HLA-C, and 
      HLA-DRB1 is required, p(1,000,000) is 0.678. The corresponding value for n = 
      7,000,000 is 0.859. In a scenario with low-resolution matching and no 
      consideration of HLA-C, p(1,000,000) is 0.863 and thus larger than p(7,000,000) 
      in the scenario with stricter matching requirements. As recent findings support 
      the importance of high-resolution matching of HLA-A, HLA-B, HLA-C, and HLA-DRB1 
      for outcomes of hematopoietic stem cell transplantation, our results are highly 
      relevant for strategic planning and resource allocation of donor centers and 
      registries.
FAU - Schmidt, Alexander H
AU  - Schmidt AH
AD  - DKMS German Bone Marrow Donor Center, Tubingen, Germany. schmidt@dkms.de
FAU - Baier, Daniel
AU  - Baier D
FAU - Solloch, Ute V
AU  - Solloch UV
FAU - Stahr, Andrea
AU  - Stahr A
FAU - Cereb, Nezih
AU  - Cereb N
FAU - Wassmuth, Ralf
AU  - Wassmuth R
FAU - Ehninger, Gerhard
AU  - Ehninger G
FAU - Rutt, Claudia
AU  - Rutt C
LA  - eng
PT  - Journal Article
DEP - 20090813
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - *Alleles
MH  - *Donor Selection
MH  - Genetics, Population
MH  - Germany
MH  - HLA Antigens/*genetics/immunology
MH  - HLA-A Antigens/genetics/immunology
MH  - HLA-B Antigens/genetics/immunology
MH  - HLA-C Antigens/genetics/immunology
MH  - HLA-DR Antigens/genetics/immunology
MH  - HLA-DRB1 Chains
MH  - *Haplotypes
MH  - Humans
MH  - *Registries
MH  - Stem Cells/*immunology
MH  - Tissue Donors
EDAT- 2009/08/18 09:00
MHDA- 2009/12/16 06:00
CRDT- 2009/08/18 09:00
PHST- 2009/05/20 00:00 [received]
PHST- 2009/07/31 00:00 [revised]
PHST- 2009/08/10 00:00 [accepted]
PHST- 2009/08/18 09:00 [entrez]
PHST- 2009/08/18 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - S0198-8859(09)00220-1 [pii]
AID - 10.1016/j.humimm.2009.08.006 [doi]
PST - ppublish
SO  - Hum Immunol. 2009 Nov;70(11):895-902. doi: 10.1016/j.humimm.2009.08.006. Epub 
      2009 Aug 13.